Synthesis, Spectroscopic Characterization, Single-Crystal Structure, Hirshfeld Surface Analysis, and Antimicrobial Studies of 3-Acetoxy-2-methylbenzoic Anhydride

被引：14

作者：

Cakmak, Sukriye ^{[1
]}

Kansiz, Sevgi ^{[4
]}

Azam, Mohammad ^{[5
]}

Veyisoglu, Aysel ^{[1
]}

Yakan, Hasan ^{[2
]}

Min, Kim ^{[3
]}

机构：

[1] Sinop Univ, Vocat Sch Hlth Serv, Dept Med Serv & Tech, TR-57000 Sinop, Turkey

[2] Ondokuz Mayis Univ, Dept Sci & Math Educ, TR-55139 Samsun, Turkey

[3] Dongguk Univ, Dept Safety Engn, Gyeongju 780714, Gyeongbuk, South Korea

[4] Samsun Univ, Dept Fundamental Sci, Fac Engn, TR-55420 Samsun, Turkey

[5] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia

来源：

ACS OMEGA | 2022年 / 7卷 / 20期

关键词：

CARBOXYLIC-ACID ANHYDRIDES; INTERMOLECULAR INTERACTIONS; ALDEHYDES; VISUALIZATION; ESTERS; CDC; DFT;

D O I：

10.1021/acsomega.2c00879

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a novel anhydride derivative, 3-acetoxy-2-methylbenzoic anhydride (AMA), obtained from the interaction of 3-acetoxy-2-methylbenzoyl chloride with 3-acetoxy-2-methylbenzoic acid. The synthesized compound was characterized by elemental analysis, IR, H-1 NMR, and C-13 NMR spectroscopic studies and single-crystal X-ray crystallography which revealed the crystallization of AMA as monoclinic with space group P2(1)/c. A Hirshfeld surface analysis was performed to record various intermolecular interactions, indicating the stabilization of the AMA structure by the intermolecular weak C-H center dot center dot center dot O hydrogen bonds and pi center dot center dot center dot pi interactions. The title compound was screened for antibacterial and antifungal activities using a serial dilution technique under aseptic conditions. The results indicate that the title compound has significant antibacterial properties but showed no antifungal behavior.

引用

页码：17192 / 17201

页数：10

共 49 条

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