Autotaxin A protein with two faces

被引：24

作者：

Tania, Mousumi ^{[1
]}

Khan, Md Asaduzzaman ^{[1
]}

Zhang, Huaiyuan ^{[1
]}

Li, Jinhua ^{[1
]}

Song, Yuanda ^{[1
]}

机构：

[1] Cent S Univ, Dept Biochem, Sch Biol Sci & Technol, Changsha 410013, Hunan, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 401卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Lysophospholipase D; Lysophosphatidyl choline; Lysophosphatidic acid; Cyclic phosphatidic acid; Cancer; CYCLIC PHOSPHATIDIC-ACID; LYSOPHOSPHATIDIC ACID; LIPID MEDIATOR; CANCER; LPA; METASTASIS; INHIBITION; RECEPTORS; MIGRATION; ANALOGS;

D O I：

10.1016/j.bbrc.2010.09.114

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autotaxin (ATX) is a catalytic protein which possesses lysophospholipase D activity and thus involved in cellular membrane lipid metabolism and remodeling Primarily ATX was thought as a culprit protein for cancer which potently stimulates cancer cell proliferation and tumor cell motility augments the tumorigenicity and induces angiogenic responses The product of ATX catalyzed reaction lysophosphatidic acid (LPA) is a potent mitogen which facilitates cell proliferation and migration neurite retraction platelet aggregation smooth muscle contraction actin stress formation and cytokine and chemokine secretion In addition to LPA formation later ATX has been found to catalyze the formation of cyclic phosphatidic acid (cPA) which have antitumor role by antimitogenic regulation of cell cycle inhibition of cancer invasion and metastasis Furthermore the very attractive information to the scientists is that the LPA/cPA formation can be altered at different physiological conditions Thus the dual role of ATX with the scope of product manipulation has made ATX a novel target for cancer treatment (C) 2010 Elsevier Inc All rights reserved

引用

页码：493 / 497

页数：5

共 43 条

[1] Mechanisms of lysophosphatidic acid production [J].

Aoki, J .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2004, 15 (05) :477-489

[2] Two pathways for lysophosphatidic acid production [J].

Aoki, Junken ;

Inoue, Asuka ;

Okudaira, Shinichi .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2008, 1781 (09) :513-518

[3] Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis [J].

Baker, Daniel L. ;

Fujiwara, Yuko ;

Pigg, Kathryn R. ;

Tsukahara, Ryoko ;

Kobayashi, Susumu ;

Murofushi, Hiromu ;

Uchiyama, Ayako ;

Murakami-Murofushi, Kimiko ;

Koh, Eunjin ;

Bandle, Russell W. ;

Byun, Hoe-Sup ;

Bittman, Robert ;

Fan, Dominic ;

Murph, Mandi ;

Mills, Gordon B. ;

Tigyi, Gabor .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (32) :22786-22793

[4]

CHRISTIE WW, PHOSPHATIDIC ACID LY

[5]

Clair T, 2003, CANCER RES, V63, P5446

[6] α- and β-Substituted phosphonate analogs of LPA as autotaxin inhibitors [J].

Cui, Peng ;

McCalmont, William F. ;

Tomsig, Jose L. ;

Lynch, Kevin R. ;

Macdonald, Timothy L. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (05) :2212-2225

[7] Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors [J].

Cui, Peng ;

Tomsig, Jose L. ;

McCalmont, William F. ;

Lee, Sangderk ;

Becker, Christopher J. ;

Lynch, Kevin R. ;

Macdonald, Timothy L. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (06) :1634-1640

[8] Naturally occurring analogs of lysophosphatidic acid elicit different cellular responses through selective activation of multiple receptor subtypes [J].

Fischer, DJ ;

Liliom, K ;

Guo, Z ;

Nusser, N ;

Virág, T ;

Murakami-Murofushi, K ;

Kobayashi, S ;

Erickson, JR ;

Sun, GP ;

Miller, DD ;

Tigyi, G .

MOLECULAR PHARMACOLOGY, 1998, 54 (06) :979-988

[9] ATX expression and LPA signalling are vital for the development of the nervous system [J].

Fotopoulou, Stella ;

Oikonomou, Nikos ;

Grigorieva, Elena ;

Nikitopoulou, Ioanna ;

Paparountas, Triantafillos ;

Thanassopoulou, Artemis ;

Zhao, Zhenwen ;

Xu, Yan ;

Kontoyiannis, Dimitris L. ;

Remboutsika, Eumorphia ;

Aidinis, Vassilis .

DEVELOPMENTAL BIOLOGY, 2010, 339 (02) :451-464

[10] Conversion of lysophospholipids to cyclic lysophosphatidic acid by phospholipase D [J].

Friedman, P ;

Haimovitz, R ;

Markman, O ;

Roberts, MF ;

Shinitzky, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (02) :953-957

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