Diastereoselective Reductive Aldol Reaction of Enones to Ketones Catalyzed by Halogenotin Hydride

被引：9

作者：

Shibata, Ikuya ^{[1
]}

Tsunoi, Shinji ^{[1
]}

Sakabe, Kumiko ^{[1
]}

Miyamoto, Shinji ^{[1
]}

Kato, Hirofumi ^{[2
]}

Nakajima, Hideto ^{[2
]}

Yasuda, Makoto ^{[2
]}

Baba, Akio ^{[2
]}

机构：

[1] Osaka Univ, Res Ctr Environm Preservat, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Appl Chem, Grad Sch Engn, Suita, Osaka 5650871, Japan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 45期

关键词：

aldol reaction; diastereoselectivity; enones; ketones; reduction; ALPHA; BETA-UNSATURATED KETONES; INDIUM HYDRIDE; VINYL KETONES; RHODIUM; SELECTIVITY; GENERATION; ALDEHYDES; HYDROGEN;

D O I：

10.1002/chem.201002108

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It's in the tin: The reductive aldol reaction of enones has been established by the Bu2SnClH (cat.)/Ph2SiH2/MeOH system (see scheme). The reaction of enones with α-ketoesters or α-alkoxyketones is highly diastereoselective through a chelation-controlled mechanism. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：13335 / 13338

页数：4

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