Distinctive features of severe SARS-CoV-2 pneumonia

被引：52

作者：

Budinger, G. R. Scott ^{[1
]}

V. Misharin, Alexander ^{[1
]}

Ridge, Karen M. ^{[1
]}

Singer, Benjamin D. ^{[1
]}

Wunderink, Richard G. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Med, Div Pulm & Crit Care Med, Chicago, IL USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2021年 / 131卷 / 14期

关键词：

CORONAVIRUS DISEASE 2019; COMMUNITY-ACQUIRED PNEUMONIA; RESPIRATORY SYNDROME CORONAVIRUS; COLONY-STIMULATING FACTOR; CRITICALLY-ILL PATIENTS; ALVEOLAR MACROPHAGES; DISTRESS-SYNDROME; H1N1; INFLUENZA; UNITED-STATES; HIGHER RISK;

D O I：

10.1172/JCI149412

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The coronavirus disease 2019 (COVID-19) pandemic is among the most important public health crises of our generation. Despite the promise of prevention offered by effective vaccines, patients with severe COVID-19 will continue to populate hospitals and intensive care units for the foreseeable future. The most common clinical presentation of severe COVID-19 is hypoxemia and respiratory failure, typical of the acute respiratory distress syndrome (ARDS). Whether the clinical features and pathobiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia differ from those of pneumonia secondary to other pathogens is unclear. This uncertainty has created variability in the application of historically proven therapies for ARDS to patients with COVID-19. We review the available literature and find many similarities between patients with ARDS from pneumonia attributable to SARS-CoV-2 versus other respiratory pathogens. A notable exception is the long duration of illness among patients with COVID-19, which could result from its unique pathobiology. Available data support the use of care pathways and therapies proven effective for patients with ARDS, while pointing to unique features that might be therapeutically targeted for patients with severe SARS-CoV-2 pneumonia.

引用

页数：13

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