Thyroid hormone receptor and lipid regulation

被引：0

作者：

Webb, Paul ^{[1
]}

机构：

[1] Methodist Hosp, Res Inst, Ctr Diabet Res, Houston, TX 77030 USA

来源：

CURRENT OPINION IN INVESTIGATIONAL DRUGS | 2010年 / 11卷 / 10期

关键词：

Cholesterol; dyslipidemia; lipid metabolism; lipoprotein; selective modulation; thyroid hormone receptor; triglyceride; NONALCOHOLIC FATTY LIVER; 14; RANDOMIZED-TRIALS; CHOLESTEROL; 7-ALPHA-HYDROXYLASE; AGONIST GC-1; LDL RECEPTOR; MICE; RATS; TRANSPORT; STATINS; ACID;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The concept of thyroid hormone (TH) analogs that retain the beneficial effects of TH excess on lipid lowering and fat metabolism, while avoiding any harmful effects on the heart, muscle, bone and other tissues, has interested scientists and physicians for several decades. While there have been many attempts to develop selective TH receptor (TR) modulators (STRMs) for safe lipid lowering, these approaches have failed consistently. This review details recent advances in the development of TR beta subtype- and liver-selective STRM analogs, and presents the results of preliminary clinical trials with one of these compounds, eprotirome (KB-2115; Karo Bio AB).

引用

页码：1135 / 1142

页数：8

共 45 条

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