Clinical Characteristics of Aspirin-Exacerbated Respiratory Disease

被引：11

作者：

Stevenson, Donald D. ^{[1
]}

White, Andrew A. ^{[1
]}

机构：

[1] Scripps Clin, Div Allergy Asthma & Immunol, 3811 Valley Ctr Dr 599, San Diego, CA 92130 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2016年 / 36卷 / 04期

关键词：

Aspirin; Nonsteroidal anti-inflammatory drugs; Nasal polyposis; Quality of life; Asthma; Chronic rhinosinusitis; Cyclooxygenase; 1; TO-TREAT ASTHMA; SAMTERS TRIAD; SENSITIVE RHINOSINUSITIS; CROSS-SENSITIVITY; ADVERSE REACTIONS; NATURAL-HISTORY; PREVALENCE; DESENSITIZATION; INTOLERANCE; CHALLENGES;

D O I：

10.1016/j.iac.2016.06.002

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Aspirin-exacerbated respiratory disease is a significant endotype of both asthma and chronic rhinosinusitis with nasal polyps. The disease demonstrates what seems to be a unified inflammatory mechanism culminating in highly eosinophilic nasal polyp disease and asthma. The rate of polyp recurrence and morbidity from asthma exacerbations are significant and warrant separating this group diagnostically from aspirin-tolerant peers. Given the unique anti-inflammatory effects of aspirin and the evolving landscape of new, targeted biologic treatments, it is even more incumbent to consider this diagnosis and offer patients treatment specific for the disease.

引用

页码：643 / +

页数：14

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