Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids

被引：53

作者：

Smith, Ryan C. ^{[1
,2
,3
]}

Tabar, Viviane ^{[1
,2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Brain Tumor Ctr, Dept Neurosurg, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Ctr Stem Cell Biol, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Louis V Gerstner Jr Grad Sch Biomed Sci, New York, NY 10065 USA

来源：

CELL STEM CELL | 2019年 / 24卷 / 01期

关键词：

MODELING COLORECTAL-CANCER; MICROGLIA-LIKE CELLS; PROGENITOR CELLS; IN-VITRO; DIFFERENTIATION; DISEASE; MUTATIONS; GENOME; REVEAL; PROGRESSION;

D O I：

10.1016/j.stem.2018.11.012

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Cell lines and animal models have provided the foundation of cancer research for many years. However, human pluripotent stem cells (hPSCs) and organoids are increasingly enabling insights into tumor development, progression, and treatment. Here, we review recent studies using hPSCs to elucidate the reciprocal roles played by genetic alterations and cell identity in cancer formation. We also review studies using human organoids as models that recapitulate both intra- and inter-tumoral heterogeneity to gain new insights into tumorigenesis and treatment responses. Finally, we highlight potential opportunities for cancer research using hPSC-derived organoids and genome editing in the future.

引用

页码：12 / 24

页数：13

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