Multi-component assembly of the bicyclic core associated with the tRNA synthetase inhibitors SB-203207 and SB-203208. Application to the synthesis of biologically active analogues

被引：22

作者：

Banwell, MG ^{[1
]}

Crasto, CF

Easton, CJ

Karoli, T

March, DR

Nairn, MR

O'Hanlon, PJ

Oldham, MD

Willis, AC

Yue, WM

机构：

[1] Australian Natl Univ, Inst Adv Studies, Res Sch Chem, Canberra, ACT 0200, Australia

[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 21期

关键词：

D O I：

10.1039/b104890m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ketone (+/-)- 5, which embodies the bicyclic core associated with the title tRNA synthetase inhibitors 1 and 2, has been prepared via a three-component coupling reaction involving 2-( hydroxymethyl) cyclopent-2-enone (15), methylamine (6) and propiolamide (10); straightforward elaboration of the readily derived acetates ()- 21 and (+)- 21 has provided the biologically active analogues 23 and 24, respectively, of the title compounds.

引用

页码：2210 / 2211

页数：2

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