Role of Paip1 on angiogenesis and invasion in pancreatic cancer

被引：18

作者：

Guan, Hongjian ^{[1
,2
,3
]}

Li, Nan ^{[1
,2
,4
]}

Wang, Xinyue ^{[1
,2
,4
]}

Shan, Xinyu ^{[3
]}

Li, Zhuhu ^{[1
,2
]}

Lin, Zhenhua ^{[1
,2
,4
]}

机构：

[1] Yanbian Univ, Med Coll, Dept Pathol, Yanji 133002, Peoples R China

[2] Yanbian Univ, Med Coll, Canc Res Ctr, Yanji 133002, Peoples R China

[3] Yanbian Univ Hosp, Dept Med, Yanbian 133000, Jilin, Peoples R China

[4] Dept Jilin Prov, Key Lab Sci & Technol, Yanji 133002, Peoples R China

来源：

EXPERIMENTAL CELL RESEARCH | 2019年 / 376卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Paip1; Pancreatic cancer; Metastasis; Angiogenesis; TRANSLATION INITIATION; PROGRESSION; PROTEIN;

D O I：

10.1016/j.yexcr.2019.01.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Poly(A)-binding protein-interacting protein 1 (Paip1) was discovered as a modulator of translation initiation as a result of binding to PABP. Increasing evidence suggested that Paip1 has been implicated in several pathogenic roles. However, its clinical significance and underlying molecular mechanisms in Pancreatic cancer (PC) remain uncertain. In our present study, we found that Paip1 was over-expressed in human PC tissues. As well as poor survival, the over-expression of Paip1 was associated with lymph node (LN) metastasis of the PC samples analyzed. Paip1 silencing inhibits PC cell proliferation, metastasis, and angiogenesis, whereas over-expression of Paip1 produces the opposite effects. In all, we proposed that Paip1 contributes to PC progression and appears to be a valid prognostic factor of PC.

引用

页码：198 / 209

页数：12

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