Global hotspots and future prospects of chimeric antigen receptor T-cell therapy in cancer research: a bibliometric analysis

被引：11
作者：
Liu, Ming [1 ,2 ]
Gao, Ya [1 ,2 ]
Yuan, Yuan [3 ]
Shi, Shuzhen [1 ,2 ]
Yang, Kelu [4 ]
Wu, Jiarui [5 ]
Zhang, Junhua [6 ]
Tian, Jinhui [1 ,2 ]
机构：
[1] Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China
[2] Key Lab Evidence Based Med Knowledge Translat Gan, Lanzhou 730000, Peoples R China
[3] Gansu Univ Chinese Med, Lanzhou 730000, Peoples R China
[4] Lanzhou Univ, Sch Nursing, Lanzhou 730000, Peoples R China
[5] Beijing Univ Chinese Med, Sch Chinese Mat Med, Dept Clin Chinese Pharm, Beijing 100000, Peoples R China
[6] Tianjin Univ Tradit Chinese Med, Evidence Based Med Ctr, Tianjin 300193, Peoples R China
来源：
FUTURE ONCOLOGY | 2020年 / 16卷 / 10期
关键词：
bibliometric analysis; CAR T-cell; CiteSpace; VOSviewer; AMERICAN SOCIETY; PROGRESS; SCIENCE; TRENDS; FIELD;
D O I：
10.2217/fon-2019-0810
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: Our study aimed to analyze the characteristics of papers published on CAR T-cell in the field of cancer and explore the existing hot topics and prospects. Materials & methods: We explored the global hotspots and future prospects regarding CAR T-cell therapy in cancer research. Papers of CAR T-cell research were retrieved from the Web of Science database. Analysis was performed using VOSviewer, CiteSpace and Excel software. Results: A total number of 1994 papers related to CAR T-cell research of cancer were included. Molecular Therapy published the most papers (n = 85, 4.26%). A total of 9792 authors participated in the publication of all papers. 62 countries and 2065 institutions have participated in the publication of all papers. Conclusion: Research trends are to improve the immunosuppressive microenvironment of cancer, optimize the structure of CAR T-cells and develop 'super CAR T-cell' by using gene-editing technology.
引用
收藏
页码：597 / 612
页数：16
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