The effects of progesterones on blood lipids in hormone replacement therapy

被引：26
作者：
Jiang, Yifan [1 ]
Tian, Weijie [2 ]
机构：
[1] Guizhou Prov Ctr Drug Reevaluat, Guiyang 550001, Guizhou, Peoples R China
[2] Guizhou Prov Peoples Hosp, Dept Obstet & Gynecol, 83 Zhongshan East Rd, Guiyang 550002, Guizhou, Peoples R China
来源：
LIPIDS IN HEALTH AND DISEASE | 2017年 / 16卷
关键词：
Hormone replacement therapy; Progestogens; Lipids; HEALTHY POSTMENOPAUSAL WOMEN; CONJUGATED EQUINE ESTROGENS; RANDOMIZED CONTROLLED-TRIAL; CARDIOVASCULAR RISK-FACTORS; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; MEDROXYPROGESTERONE ACETATE; DIFFERENT PROGESTOGENS; NOMEGESTROL ACETATE; PLASMA-LIPIDS;
D O I：
10.1186/s12944-017-0612-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The safety of progestogens as a class has drawn much attention after the publication of data from the Women's Health Initiative (WHI) trial, particularly with respect to cardiovascular disease. Depending on the chemical structure, pharmacokinetics, receptor affinity and potency of action, progestogens have a divergent range of properties that may translate to very different clinical effects. The purpose of this review is to describe the role of varied progestogens in hormone replacement therapy (HRT), especially focusing on blood lipids, which are the most important parameters for assessing cardiovascular disease risk.
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页数：8
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