Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma arising in patient with a history of EBV-positive mucocutaneous ulcer and EBV-positive nodal polymorphous B-lymphoproliferative disorder

被引：21

作者：

Daroontum, Teerada ^{[1
,2
]}

Kohno, Kei ^{[1
]}

Inaguma, Yoko ^{[3
]}

Okamoto, Akinao ^{[3
]}

Okamoto, Masataka ^{[3
]}

Kimura, Yoshihiro ^{[4
,5
]}

Nagahama, Masato ^{[4
,5
]}

Sakakibara, Ayako ^{[6
]}

Satou, Akira ^{[7
]}

Nakamura, Shigeo ^{[1
]}

机构：

[1] Nagoya Univ Hosp, Dept Pathol & Lab Med, Nagoya, Aichi, Japan

[2] Chiang Mai Univ, Dept Pathol, Fac Med, Chiang Mai, Thailand

[3] Fujita Hlth Univ, Sch Med, Dept Hematol, Toyoake, Aichi, Japan

[4] Handa City Hosp, Dept Oral & Maxillofacial Surg, Handa, Japan

[5] Handa City Hosp, Dept Pathol, Handa, Japan

[6] Okazaki City Hosp, Dept Pathol, Okazaki, Aichi, Japan

[7] Aichi Med Univ Hosp, Dept Surg Pathol, Nagakate, Japan

来源：

PATHOLOGY INTERNATIONAL | 2019年 / 69卷 / 01期

基金：

日本学术振兴会;

关键词：

EBV-associated B-cell lymphoproliferative disorder; EBV-positive diffuse large B-cell lymphoma; EBV-positive mucocutaneous ulcer; EBV-positive nodal polymorphous B-LPD;

D O I：

10.1111/pin.12738

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Elderly patients with Epstein-Barr virus (EBV) infection are at increased risk for developing B-cell lymphoproliferative disorder (B-LPD) due to immunosenescence. Here, we describe a case of a 75-year-old man who developed an EBV-positive (EBV+) mucocutaneous ulcer (EBVMCU) in the gingiva with spontaneous regression. Eighteen months after regression, he had a cervical lymph node enlargement that was diagnosed as EBV+ nodal polymorphous B-LPD, Ann Arbor stage IA. Clinicians decided to observe his clinical course without any treatment. Fourteen months later, the patient developed EBV-positive diffuse large B-cell lymphoma (DLBCL), Ann Arbor stage IIA, and received six courses of age-adjusted dose chemotherapy and achieved a complete remission. No evidence of a clonal relationship was found among these three lesions by standard polymerase chain reaction (PCR) analysis for immunoglobulin heavy chain. However, they all had expression of PD-L1 in the EBV+ large B-cells and Hodgkin Reed-Sternberg-like cells. This is the first case report of a PD-L1-positive (PD-L1+) EBVMCU and the development of multiple EBV-driven B-LPDs in the setting of immunosenescence within a 32-month period.

引用

页码：37 / 41

页数：5

共 16 条

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