White matter lesions and hippocampal atrophy in Alzheimer's disease

被引：104
作者：
de Leeuw, FE
Barkhof, F
Scheltens, P
机构：
[1] Vrije Univ Amsterdam Med Ctr, Dept Neurol, Alzheimer Ctr, NL-1007 MB Amsterdam, Netherlands
[2] Vrije Univ Amsterdam Med Ctr, Dept Radiol, NL-1007 MB Amsterdam, Netherlands
[3] Radboud Univ Nijmegen Med Ctr, Dept Neurol, Nijmegen, Netherlands
来源：
NEUROLOGY | 2004年 / 62卷 / 02期
关键词：
D O I：
10.1212/01.WNL.0000103289.03648.AD
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
White matter lesions (WML) and hippocampal atrophy (HA) on MRI commonly co-occur in Alzheimer's disease (AD) and are thought to play a role in the etiology of AD. It is still not known whether WML and HA are independent or related. The authors investigated the relation between WML and HA in 179 patients with probable AD who had a cerebral MRI. A linear relation was found between WML and HA, especially for WML in the frontal and parieto-occipital regions. The results suggest that vascular pathology and typical AD pathology (HA) are related.
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页码：310 / 312
页数：3
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