Conjugated polymer nanoparticles for small interfering RNA delivery

被引：59

作者：

Moon, Joong Ho ^{[1
]}

Mendez, Eladio ^{[1
]}

Kim, Yong ^{[2
]}

Kaur, Aman ^{[1
]}

机构：

[1] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA

[2] UCLAs Jonsson Comprehens Canc Ctr, Dent Res Inst, UCLA Sch Dent, Div Oral Biol & Med, Los Angeles, CA 90095 USA

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 29期

关键词：

SIRNA DELIVERY; CELLS; POLYETHYLENIMINE; DNA; POLYELECTROLYTES; EFFICIENT; VECTORS;

D O I：

10.1039/c1cc10991j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Loosely aggregated conjugated polymer nanoparticles (CPNs) were used as nontoxic and efficient small interfering RNA (siRNA) delivery vehicles with delivery visualization. A significant down regulation (94%) of a target gene was achieved by transfection of HeLa cells with the CPNs/siRNA complexes, supporting CPN as a promising siRNA delivery carrier.

引用

页码：8370 / 8372

页数：3

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