Transgenerational Epigenetic Inheritance

被引：218

作者：

Boskovic, Ana ^{[1
]}

Rando, Oliver J. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01605 USA

来源：

ANNUAL REVIEW OF GENETICS, VOL 52 | 2018年 / 52卷

关键词：

epigenetics; transgenerational inheritance; germ cells; development; DIRECTED DNA METHYLATION; DOUBLE-STRANDED-RNA; PIRNA PATHWAY; HETEROCHROMATIN FORMATION; TRANSPOSABLE ELEMENTS; GENOME REGULATION; SEED DEVELOPMENT; GENE-EXPRESSION; ARABIDOPSIS; SPERM;

D O I：

10.1146/annurev-genet-120417-031404

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has been clear for decades that additional epigenetic information can be passed on to future generations. Here, we review major model systems for transgenerational epigenetic inheritance via the germline in multicellular organisms. In addition to surveying examples of epivariation that may arise stochastically or in response to unknown stimuli, we also discuss the induction of heritable epigenetic changes by genetic or environmental perturbations. Mechanistically, we discuss the increasingly well-understood molecular pathways responsible for epigenetic inheritance, with a focus on the unusual features of the germline epigenome.

引用

页码：21 / 41

页数：21

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