The role of peroxisome proliferator-activated receptor-coactivator-1 gene in skin aging

被引：0
|
作者：
Aghaei, Shahrzad [1 ]
Nilforoushzadeh, Mohammad Ali [2 ]
Aghaei, Maryam [3 ]
机构：
[1] Shahrekord Univ, Dept Genet, Shahrekord, Iran
[2] Univ Tehran Med Sci, Skin & Stem Cell Res Ctr, Tehran, Iran
[3] Isfahan Univ Med Sci, Skin Dis & Leishmaniasis Res Ctr, Esfahan, Iran
来源：
JOURNAL OF RESEARCH IN MEDICAL SCIENCES | 2016年 / 21卷
关键词：
Free radicals; mitochondria; peroxisome proliferator-activated receptor-coactivator-1; replication; skin aging; wrinkle; TRANSCRIPTIONAL COACTIVATOR; HEPATIC GLUCONEOGENESIS; GAMMA COACTIVATOR-1; UNCOUPLING PROTEIN; RECEPTOR; EXPRESSION; TISSUE; PATHOPHYSIOLOGY; MECHANISMS; LONGEVITY;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Skin aging is a continuous process that exhibits fine and deep wrinkles, thin and transparent skin, loss of underlying fat, dry skin and itch, following decreased collagen and elastin synthesis. Both extrinsic and intrinsic agents are considered in the pathogenesis on skin aging. Extrinsic factors such as sun exposure, windy and dry weather, nutrition, and lifestyle may induce premature aging, toxic-free radicals, and reactive oxygen species due to decreasing normal function of mitochondria which play the major intrinsic factors in premature skin aging. One of the major genetic factors in mitochondrial function is peroxisome proliferator-activated receptor-coactivator-1 (PGC-1) gene. This factor could delay skin aging by increasing the mitochondrial biogenesis and replication and oxidative phosphorylation and so may induce free radical scavenging. This review is focused on intrinsic skin aging and the role of PGC-1 protein in decreasing effect of aging causes.
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页数：6
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