Utility of 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrile as a precursor for the synthesis of some novel pyrimidines: antibacterial activity

被引：6

作者：

Hamid, Atef M. Abdel ^{[1
]}

Shehta, W. ^{[1
]}

机构：

[1] Zagazig Univ, Fac Sci, Dept Chem, Zagazig 44519, Egypt

来源：

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2018年 / 15卷 / 12期

关键词：

Pyrazolopyrimidine; Triazolopyrimidine; Pyrimidopyridazine; Cyclocondensation; Antibacterial; THIAZOLOPYRIMIDINES; ISOTHIOCYANATES; AGENTS;

D O I：

10.1007/s13738-018-1464-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The starting material 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrile 3 was reacted with various reagents resulting in the formation of a group of new pyrimidines and condensed pyrimidines including quinazoline 6 tetrazolopyrimidine 12, pyrazolopyrimidines 14, 18, and 19, triazolopyrimidine 16, and pyrimidopyridazine 20. The antibacterial activity was evaluated for a group of the synthesized compounds against examples of Gram-positive and Gram-negative bacteria.

引用

页码：2771 / 2779

页数：9

共 23 条

[1] Synthesis and antimicrobial evaluation of some new pyrimidines and condensed pyrimidines [J].

Abdelghani, Essam ;

Said, Said Aly ;

Assy, M. G. ;

Hamid, Atef M. Abdel .

ARABIAN JOURNAL OF CHEMISTRY, 2017, 10 :S2926-S2933

[2] Heterocyclization of thiouracil derivative: synthesis of thiazolopyrimidines, tetrazolopyrimidines and triazolopyrimidines of potential biological activity [J].

Abdelghani, Essam ;

Said, Said Aly ;

Assy, M. G. ;

Hamid, Atef M. Abdel .

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2015, 12 (10) :1809-1817

[3] Synthesis, Antioxidant, Antituomer Activities of Some New Thiazolopyrimidines, Pyrrolothiazolopyrimidines and Triazolopyrrolothiazolopyrimidines Derivatives [J].

Abu-Hashem, Ameen Ali ;

Youssef, Mohamed M. ;

Hussein, Hoda A. R. .

JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2011, 58 (01) :41-48

[4] Synthesis and comparing the antibacterial activities of pyrimidine derivatives [J].

Andrews, B. ;

Komathi, K. ;

Mohan, S. .

JOURNAL OF CHEMICAL SCIENCES, 2017, 129 (03) :335-341

[5] Synthesis and Antibacterial Evaluation of Novel Heterocyclic Compounds Containing a Sulfonamido Moiety [J].

Azab, Mohammad Emad ;

Youssef, Mohamed M. ;

El-Bordany, Eman A. .

MOLECULES, 2013, 18 (01) :832-844

[6] Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication [J].

Balzarini, J ;

McGuigan, C .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 50 (01) :5-9

[7] Principles of assessing bacterial susceptibility to antibiotics using the agar diffusion method [J].

Bonev, Boyan ;

Hooper, James ;

Parisot, Judicael .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 61 (06) :1295-1301

[8] Efficient synthesis of antifungal pyrimidines via palladium catalyzed Suzuki/Sonogashira cross-coupling reaction from Biginelli 3,4-dihydropyrimidin-2(1H)-ones [J].

Gholap, Atul R. ;

Toti, Kiran S. ;

Shirazi, Fazal ;

Deshpande, Mukund V. ;

Srinivasan, Kumar V. .

TETRAHEDRON, 2008, 64 (44) :10214-10223

[9]

Gupta Anita K., 1994, Indian Journal of Pharmacology, V26, P227

[10]

Hannah DR, 2003, J CHEM RES, P398

← 1 2 3 →