Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: A proton MR spectroscopy study

被引:378
作者
Yeung, DKW
Griffith, JF
Antonio, GE
Lee, FKH
Woo, J
Leung, PC
机构
[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Diagnost Radiol & Organ Imaging, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Community & Family Med, Shatin, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China
关键词
magnetic resonance (MR); spectroscopy; bone marrow; osteoporosis; unsaturation; fatty acids; lipids;
D O I
10.1002/jmri.20367
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To use proton magnetic resonance spectroscopy (H-1-MRS) to evaluate vertebral marrow fat, and to determine whether bone density correlates with fat content and fat unsaturation levels in postmenopausal women. Materials and Methods: Fifty-three women (mean age 70 years) underwent dual energy x-ray absorptiometry and H-1-MRS, and 12 young female controls (mean age = 28 years) under-went H-1-MRS of the lumber spine. Water and lipid peak amplitudes were measured to calculate fat content and fat unsaturation index. Spearman's correlation tests and a t-test comparison of means were applied. Results: H-1-MRS was successful in 15 normal, 15 osteopenic, and 20 osteoporotic subjects, and in all controls. Marrow fat content was significantly elevated in osteoporotic (65.5% +/- 10%) and osteopenic (63.5% +/- 9.3%) subjects compared to normal subjects (56.3% +/- 11.2%) and young controls (29% +/- 9.6%). The fat unsaturation index was significantly decreased in osteoporotic (0.091 +/- 0.013) and osteopenic (0.097 +/- 0.014) subjects compared to normal subjects (0.114 +/- 0.016) and young controls (0.127 +/- 0.031). A good inverse correlation was observed between the fat content and the unsaturation index (r(s) = -0.53, P < 0.0001). Conclusion: Osteoporosis is associated with increased marrow fat. As marrow fat increases, saturated lipids appear to increase preferentially to unsaturated lipids.
引用
收藏
页码:279 / 285
页数:7
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