The molecular relationships between apoptosis, autophagy and necroptosis

被引：142

作者：

Lalaoui, Najoua ^{[1
,2
]}

Lindqvist, Lisa M. ^{[1
,2
]}

Sandow, Jarrod J. ^{[1
,2
]}

Ekert, Paul G. ^{[1
,2
,3
,4
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Div Cell Signalling & Cell Death, Parkville, Vic 3050, Australia

[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3050, Australia

[3] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia

[4] Univ Melbourne, Royal Childrens Hosp, Dept Paediat, Parkville, Vic 3052, Australia

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2015年 / 39卷

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Caspases; Apoptosis; Autophagy; Necroptosis; RECEPTOR-INTERACTING PROTEIN; PROGRAMMED CELL-DEATH; MIXED LINEAGE KINASE; DOMAIN-LIKE PROTEIN; SIGNALING COMPLEX DISC; TUMOR-NECROSIS-FACTOR; BCL-2; FAMILY-MEMBERS; SERINE-PROTEASE; CYTOCHROME-C; TNF-ALPHA;

D O I：

10.1016/j.semcdb.2015.02.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells are constantly subjected to a vast range of potentially lethal insults, which may activate specific molecular pathways that have evolved to kill the cell. Cell death pathways are defined partly by their morphology, and more specifically by the molecules that regulate and enact them. As these pathways become more thoroughly characterized, interesting molecular links between them have emerged, some still controversial and others hinting at the physiological and pathophysiological roles these death pathways play. We describe specific molecular programs controlling cell death, with a focus on some of the distinct features of the pathways and the molecular links between them. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：63 / 69

页数：7

共 103 条

[1] Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B [J].

Adrain, C ;

Murphy, BM ;

Martin, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (06) :4663-4673

[2] Autophagy Provides Nutrients but Can Lead to Chop-dependent Induction of Bim to Sensitize Growth Factor-deprived Cells to Apoptosis [J].

Altman, Brian J. ;

Wofford, Jessica A. ;

Zhao, Yuxing ;

Coloff, Jonathan L. ;

Ferguson, Emily C. ;

Wieman, Heather L. ;

Day, Amanda E. ;

Ilkayeva, Olga ;

Rathmell, Jeffrey C. .

MOLECULAR BIOLOGY OF THE CELL, 2009, 20 (04) :1180-1191

[3] Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes [J].

Basit, F. ;

Cristofanon, S. ;

Fulda, S. .

CELL DEATH AND DIFFERENTIATION, 2013, 20 (09) :1161-1173

[4] FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells [J].

Bell, Bryan D. ;

Leverrier, Sabrina ;

Weist, Brian M. ;

Newton, Ryan H. ;

Arechiga, Adrian F. ;

Luhrs, Keith A. ;

Morrissette, Naomi S. ;

Walsh, Craig M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (43) :16677-16682

[5] cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination [J].

Bertrand, Mathieu J. M. ;

Milutinovic, Snezana ;

Dickson, Kathleen M. ;

Ho, Wai Chi ;

Boudreault, Alain ;

Durkin, Jon ;

Gillard, John W. ;

Jaquith, James B. ;

Morris, Stephen J. ;

Barker, Philip A. .

MOLECULAR CELL, 2008, 30 (06) :689-700

[6] The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation [J].

Bonnet, Marion C. ;

Preukschat, Daniela ;

Welz, Patrick-Simon ;

van Loo, Geert ;

Ermolaeva, Maria A. ;

Bloch, Wilhelm ;

Haase, Ingo ;

Pasparakis, Manolis .

IMMUNITY, 2011, 35 (04) :572-582

[7] Proapoptotic Bcl-2 relative bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity [J].

Bouillet, P ;

Metcalf, D ;

Huang, DCS ;

Tarlinton, DM ;

Kay, TWH ;

Köntgen, F ;

Adams, JM ;

Strasser, A .

SCIENCE, 1999, 286 (5445) :1735-1738

[8] Perforin deficiency and susceptibility to cancer [J].

Brennan, A. J. ;

Chia, J. ;

Trapani, J. A. ;

Voskoboinik, I. .

CELL DEATH AND DIFFERENTIATION, 2010, 17 (04) :607-615

[9] Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis [J].

Cai, Zhenyu ;

Jitkaew, Siriporn ;

Zhao, Jie ;

Chiang, Hsueh-Cheng ;

Choksi, Swati ;

Liu, Jie ;

Ward, Yvona ;

Wu, Ling-gang ;

Liu, Zheng-Gang .

NATURE CELL BIOLOGY, 2014, 16 (01) :55-+

[10] Antigen-mediated T cell expansion regulated by parallel pathways of death [J].

Ch'en, Irene L. ;

Beisner, Daniel R. ;

Degterev, Alexei ;

Lynch, Candace ;

Yuan, Junying ;

Hoffmann, Alexander ;

Hedrick, Stephen M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (45) :17463-17468

← 1 2 3 4 5 6 7 8 9 10 →