Resolution of inflammation: a new therapeutic frontier

被引：682

作者：

Fullerton, James N. ^{[1
]}

Gilroy, Derek W. ^{[1
]}

机构：

[1] UCL, Div Med, Ctr Clin Pharmacol & Therapeut, 5 Univ St, London WC1E 6JJ, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2016年 / 15卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

NF-KAPPA-B; CHRONIC GRANULOMATOUS-DISEASE; NECROSIS-FACTOR-ALPHA; MELANOCYTE-STIMULATING HORMONE; APOPTOTIC CELL CLEARANCE; DENDRITIC CELLS; NEUTROPHIL APOPTOSIS; RESOLVIN E1; MACROPHAGE-PHENOTYPE; HYDROGEN-SULFIDE;

D O I：

10.1038/nrd.2016.39

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory limbs of inflammation, with mixed success. However, insight into the pathways by which inflammation is resolved has highlighted novel opportunities to pharmacologically manipulate these processes - a strategy that might represent a complementary (and perhaps even superior) therapeutic approach. This Review discusses the state of the art in the biology of resolution of inflammation, highlighting the opportunities and challenges for translational research in this field.

引用

页码：551 / 567

页数：17

共 239 条

[51] Autophagy in infection, inflammation and immunity [J].

Deretic, Vojo ;

Saitoh, Tatsuya ;

Akira, Shizuo .

NATURE REVIEWS IMMUNOLOGY, 2013, 13 (10) :722-737

[52] Human CD14 mediates recognition and phagocytosis of apoptotic cells [J].

Devitt, A ;

Moffatt, OD ;

Raykundalia, C ;

Capra, JD ;

Simmons, DL ;

Gregory, CD .

NATURE, 1998, 392 (6675) :505-509

[53] Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105 [J].

Divanovic, S ;

Trompette, A ;

Atabani, SF ;

Madan, R ;

Golenbock, DT ;

Visintin, A ;

Finberg, RW ;

Tarakhovsky, A ;

Vogel, SN ;

Belkaid, Y ;

Kurt-Jones, EA ;

Karp, CL .

NATURE IMMUNOLOGY, 2005, 6 (06) :571-578

[54] Adrenocorticotropic Hormone, Melanocyte-stimulating Hormone, and the Melanocortin Receptors: Revisiting the Work of Robert Schwyzer A Thirty-Year Retrospective [J].

Dores, Robert M. .

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY, 2009, 1163 :93-100

[55] Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis [J].

Drechsler, Maik ;

Megens, Remco T. A. ;

van Zandvoort, Marc ;

Weber, Christian ;

Soehnlein, Oliver .

CIRCULATION, 2010, 122 (18) :1837-+

[56] Hydrogen sulfide and resolution of acute inflammation: A comparative study utilizing a novel fluorescent probe [J].

Dufton, Neil ;

Natividad, Jane ;

Verdu, Elena F. ;

Wallace, John L. .

SCIENTIFIC REPORTS, 2012, 2

[57] Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation [J].

El Kebir, Driss ;

Gjorstrup, Per ;

Filep, Janos G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (37) :14983-14988

[58] Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance [J].

Elliott, Michael R. ;

Chekeni, Faraaz B. ;

Trampont, Paul C. ;

Lazarowski, Eduardo R. ;

Kadl, Alexandra ;

Walk, Scott F. ;

Park, Daeho ;

Woodson, Robin I. ;

Ostankovich, Marina ;

Sharma, Poonam ;

Lysiak, Jeffrey J. ;

Harden, T. Kendall ;

Leitinger, Norbert ;

Ravichandran, Kodi S. .

NATURE, 2009, 461 (7261) :282-U165

[59] Galectin-1 receptors in different cell types [J].

Elola, MT ;

Chiesa, ME ;

Alberti, AF ;

Mordoh, J ;

Fink, NE .

JOURNAL OF BIOMEDICAL SCIENCE, 2005, 12 (01) :13-29

[60] Dynamic Interplay among Monocyte-Derived, Dermal, and Resident Lymph Node Dendritic Cells during the Generation of Vaccine Immunity to Fungi [J].

Ersland, Karen ;

Wuethrich, Marcel ;

Klein, Bruce S. .

CELL HOST & MICROBE, 2010, 7 (06) :474-487

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