Wound Pathogens: Investigating Antimicrobial Activity of Commercial Essential Oil Combinations against Reference Strains

被引：15
作者：
Orchard, Ane [1 ]
Viljoen, Alvaro [2 ,3 ]
van Vuuren, Sandy [1 ]
机构：
[1] Univ Witwatersrand, Dept Pharm & Pharmacol, Fac Hlth Sci, Johannesburg, South Africa
[2] Tshwane Univ Technol, Dept Pharmaceut Sci, Fac Sci, Private Bag X680, ZA-0001 Pretoria, South Africa
[3] Tshwane Univ Technol, Dept Pharmaceut Sci, SAMRC Herbal Drugs Res Unit, Private Bag X680, ZA-0001 Pretoria, South Africa
来源：
CHEMISTRY & BIODIVERSITY | 2018年 / 15卷 / 12期
基金：
新加坡国家研究基金会;
关键词：
aromatherapy; infections; antibacterial activity; wounds; skin; biological activity; ANTIBACTERIAL ACTIVITY; CHEMICAL-COMPOSITION; L; CINNAMALDEHYDE; ANTIFUNGAL; TOXICITY; ULCERS; PLANTS; COST;
D O I：
10.1002/cbdv.201800405
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study aimed to determine the antimicrobial activity of 247 essential oil combinations against the reference strains of wound pathogens. Essential oil combinations were investigated for antimicrobial activity against five pathogens. The minimum inhibitory concentration (MIC) assay was used and the fractional inhibitory concentration index (sigma FIC) calculated to determine interactions between selected oils. Twenty-six combinations displayed broad-spectrum antimicrobial activity against all five reference strains and several displayed synergy against more than one pathogen. The combination of Santalum austrocaledonicum (sandalwood) with Commiphora myrrha (myrrh) displayed noteworthy antimicrobial activity against all five reference strains and synergy against four (MIC values 0.03-1.00 mg/ml and sigma FIC values 0.19-1.00 mg/ml) pathogens. No antagonism was observed. Santalum spp. and Vetiveria zizanioides essential oils contributed the most to antimicrobial activity in combination. Essential oil combinations are presented as a viable option in wound therapy.
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页数：29
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