Alpha-synuclein oligomers: a new hope

被引:265
作者
Bengoa-Vergniory, Nora [1 ]
Roberts, Rosalind F. [2 ]
Wade-Martins, Richard [1 ]
Alegre-Abarrategui, Javier [1 ]
机构
[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford Parkinsons Dis Ctr, South Parks Rd, Oxford OX1 3QT, England
[2] McGill Univ, Montreal Neurol Inst, 3801 Rue Univ, Montreal, PQ H3A 2B4, Canada
关键词
Alpha-synuclein; Parkinson's; Oligomers; Aggregation; Detection-method; BETA-AMYLOID FIBRILS; PARKINSONS-DISEASE; LEWY BODIES; MONOCLONAL-ANTIBODIES; ALZHEIMERS-DISEASE; GENE DUPLICATION; COMMON MECHANISM; BRAIN PATHOLOGY; TRANSGENIC MICE; ELEVATED LEVELS;
D O I
10.1007/s00401-017-1755-1
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Alpha-synuclein is a protein implicated in Parkinson's disease and thought to be one of the main pathological drivers in the disease, although it remains unclear how this protein elicits its neurotoxic effects. Recent findings indicate that the assembly of toxic oligomeric species of alpha-synuclein may be one of the key processes for the pathology and spread of the disease. The absence of a sensitive in situ detection method has hindered the study of these oligomeric species and the role they play in the human brain until recently. In this review, we assess the evidence for the toxicity and prion-like activity of oligomeric forms of alpha-synuclein and discuss the advances in our understanding of the role of alpha-synuclein in Parkinson's disease that may be brought about by the specific and sensitive detection of distinct oligomeric species in post-mortem patient brain. Finally, we discuss current approaches being taken to therapeutically target alpha-synuclein oligomers and their implications.
引用
收藏
页码:819 / 838
页数:20
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