Time-Gated Luminescence Detection of Enzymatically Produced Hydrogen Sulfide: Design, Synthesis, and Application of a Lanthanide-Based Probe

被引：25
作者：
Yao, Yao [1 ]
Delgado-Rivera, Loruhama [2 ,3 ]
Afsari, Hamid Samareh [1 ]
Yin, Liang [2 ,3 ]
Thatcher, Gregory R. J. [2 ,3 ]
Moore, Terry W. [2 ,3 ]
Miller, Lawrence W. [1 ]
机构：
[1] Univ Illinois, Dept Chem, 845 W Taylor St,MC 111, Chicago, IL 60607 USA
[2] Univ Illinois, UlCtr Drug Discovery, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA
[3] Univ Illinois, Canc Ctr, Chicago, IL 60607 USA
来源：
INORGANIC CHEMISTRY | 2018年 / 57卷 / 02期
基金：
美国国家卫生研究院;
关键词：
CYSTATHIONINE; INHIBITION; H2S; IDENTIFICATION; CHEMISTRY; INSIGHTS; EUROPIUM; TERBIUM; COPPER;
D O I：
10.1021/acs.inorgchem.7b02533
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Hydrogen sulfide (H2S) is now recognized as an important gaseous transmitter that is involved in a variety of biological processes. Here, we report the design and synthesis of a luminescent lanthanide biosensor for H2S, LP2-Cu(II)-Ln(III), a heterobinudear metal complex that uses Cu(II) decomplexation to control milli-second-scale-lifetime-Tb(III)- or Eu(III)-emission intensity. LP2-Cu(II)-Ln(III) responded rapidly, selectively, and with high sensitivity to aqueous H2S. The probe's potential for biological applications was verified by measuring the H2S generated by the slow releasing chemical-sulfide-donor GYY4147, by cystathionine gamma-lyase (CSE), and by Na2S-stimulated HeLa cells.
引用
收藏
页码：681 / 688
页数：8
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