Knocking at the door of the unborn child: engineered nanoparticles at the human placental barrier

被引：48

作者：

Buerki-Thurnherr, Tina ^{[1
]}

von Mandach, Ursula ^{[2
]}

Wick, Peter ^{[1
]}

机构：

[1] EMPA Swiss Fed Labs Mat Testing & Res, Lab Mat Biol Interact, CH-9014 St Gallen, Switzerland

[2] Univ Zurich Hosp, Dept Obstet, CH-8091 Zurich, Switzerland

来源：

SWISS MEDICAL WEEKLY | 2012年 / 142卷

基金：

瑞士国家科学基金会;

关键词：

transplacental transfer; nanoparticles; uptake mechanisms; PRESCRIPTION DRUG-USE; AIR-POLLUTION; RAT PLACENTA; TRANSTROPHOBLASTIC CHANNELS; FETAL EXPOSURE; PREGNANT MICE; DNA-DAMAGE; PERFUSION; PARTICLES; CELL;

D O I：

10.4414/smw.2012.13559

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Exposure of pregnant women and their unborn children to engineered nanoparticles (NPs) is not yet of major public concern. However, this may soon change in light of the ever-increasing production of NPs and the continuous appearance of novel NP-containing consumer products. However, NPs may not only pose risks to exposed individuals; they offer major potential for the development of novel therapeutic strategies to treat specifically either the mother or the developing foetus. Hence there is every reason to explore the transplacental transfer of engineered NPs in more detail, and to find answers to the vast number of open questions in this fascinating field of research.

引用

页数：9

共 55 条

[1] Ex vivo perfusion of the human placental cotyledon:: implications for anesthetic pharmacology [J].