A new 9-nor-atractylodin from Atractylodes lancea and the antibacterial activity of the atractylodin derivatives

被引：22
|
作者：
Chen, Yanjun [1 ]
Wu, Yuxue [1 ]
Wang, Hexiang [2 ]
Gao, Kun [1 ,2 ]
机构：
[1] Zhejiang Univ, Sch Biotechnol & Chem Engn, Ningbo Inst Technol, Ningbo 315100, Zhejiang, Peoples R China
[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
来源：
FITOTERAPIA | 2012年 / 83卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Atractylodes lancea; 9-Nor-atractylodin; Antibacterial activity; CYTOPROTECTIVE ACTIVITY; ANALOGS;
D O I：
10.1016/j.fitote.2011.10.015
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new compound, namely, 9-nor-atractylodin (1) and one known atractylodin (2) were isolated from the rhizomes of Atractylodes lancea. The structural modifications of atractylodin were carried out and a series of atractylodin derivatives (3-10) were obtained. The antibacterial activities of 1-10 were examined against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Compounds 4 and 8, which contained the alpha, beta-unsaturated carbonyl fragment, were found to be active against E. coli and S. aureus. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：199 / 203
页数：5
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