A new 9-nor-atractylodin from Atractylodes lancea and the antibacterial activity of the atractylodin derivatives

被引：22

作者：

Chen, Yanjun ^{[1
]}

Wu, Yuxue ^{[1
]}

Wang, Hexiang ^{[2
]}

Gao, Kun ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Sch Biotechnol & Chem Engn, Ningbo Inst Technol, Ningbo 315100, Zhejiang, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

来源：

FITOTERAPIA | 2012年 / 83卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Atractylodes lancea; 9-Nor-atractylodin; Antibacterial activity; CYTOPROTECTIVE ACTIVITY; ANALOGS;

D O I：

10.1016/j.fitote.2011.10.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new compound, namely, 9-nor-atractylodin (1) and one known atractylodin (2) were isolated from the rhizomes of Atractylodes lancea. The structural modifications of atractylodin were carried out and a series of atractylodin derivatives (3-10) were obtained. The antibacterial activities of 1-10 were examined against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Compounds 4 and 8, which contained the alpha, beta-unsaturated carbonyl fragment, were found to be active against E. coli and S. aureus. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：199 / 203

页数：5

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