A new 9-nor-atractylodin from Atractylodes lancea and the antibacterial activity of the atractylodin derivatives

被引：22

作者：

Chen, Yanjun ^{[1
]}

Wu, Yuxue ^{[1
]}

Wang, Hexiang ^{[2
]}

Gao, Kun ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Sch Biotechnol & Chem Engn, Ningbo Inst Technol, Ningbo 315100, Zhejiang, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

来源：

FITOTERAPIA | 2012年 / 83卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Atractylodes lancea; 9-Nor-atractylodin; Antibacterial activity; CYTOPROTECTIVE ACTIVITY; ANALOGS;

D O I：

10.1016/j.fitote.2011.10.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new compound, namely, 9-nor-atractylodin (1) and one known atractylodin (2) were isolated from the rhizomes of Atractylodes lancea. The structural modifications of atractylodin were carried out and a series of atractylodin derivatives (3-10) were obtained. The antibacterial activities of 1-10 were examined against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Compounds 4 and 8, which contained the alpha, beta-unsaturated carbonyl fragment, were found to be active against E. coli and S. aureus. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：199 / 203

页数：5

共 14 条

[1]

ANNABELLE LK, 2003, J ORG CHEM, V68, P6810

[2]

[Anonymous], THESIS U DUSSELDORF

[3] Gastric cytoprotective activity of ilicic aldehyde:: Structure-activity relationships [J].

Donadel, OJ ;

Guerreiro, E ;

María, AO ;

Wendel, G ;

Enriz, RD ;

Giordano, OS ;

Tonn, CE .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (15) :3547-3550

[4] Synthesis of naturally occurring polyacetylenes via a bis-silylated diyne [J].

Fiandanese, Vito ;

Bottalico, Daniela ;

Marchese, Giuseppe ;

Punzi, Angela .

TETRAHEDRON, 2006, 62 (21) :5126-5132

[5] STRUCTURE ACTIVITY RELATIONSHIP IN THE GASTRIC CYTOPROTECTIVE EFFECT OF SEVERAL SESQUITERPENE LACTONES [J].

GIORDANO, OS ;

PESTCHANKER, MJ ;

GUERREIRO, E ;

SAAD, JR ;

ENRIZ, RD ;

RODRIGUEZ, AM ;

JAUREGUI, EA ;

GUZMAN, J ;

MARIA, AOM ;

WENDEL, GH .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (13) :2452-2458

[6] Synthesis and biological evaluation of a natural ester sintenin and its synthetic analogues [J].

Hu, LH ;

Zou, HB ;

Gong, JX ;

Li, HB ;

Yang, LX ;

Cheng, W ;

Zhou, CX ;

Bai, H ;

Guéritte, F ;

Zhao, Y .

JOURNAL OF NATURAL PRODUCTS, 2005, 68 (03) :342-348

[7] HEPATIC NECROSIS CAUSED BY FUROSEMIDE [J].

MITCHELL, JR ;

POTTER, WZ ;

HINSON, JA ;

JOLLOW, DJ .

NATURE, 1974, 251 (5475) :508-511

[8] STUDIES ON COMPONENTS OF ATRACTYLODES .2. NEW POLYACETYLENIC COMPOUNDS IN RHIZOME OF ATRACTYLODES-LANCEA DE CANDOLLE VAR CHINENSIS KITAMURA [J].

NISHIKAWA, Y ;

YASUDA, I ;

WATANABE, Y ;

SETO, T .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1976, 96 (11) :1322-1326

[9] Structure-cytoprotective activity relationship of simple molecules containing an alpha,beta-unsaturated carbonyl system [J].

Rodriguez, AM ;

Enriz, RD ;

Santagata, LN ;

Jauregui, EA ;

Pestchanker, MJ ;

Giordano, OS .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (12) :1827-1834

[10] Avocadofurans and their tetrahydrofuran analogues: Comparison of growth inhibitory and insecticidal activity [J].

Rodriguez-Saona, C ;

Maynard, DF ;

Phillips, S ;

Trumble, JT .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2000, 48 (08) :3642-3645

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