Biochemical activities of low molecular weight chitosans derived from squid pens

被引：43

作者：

Huang, Jun ^{[2
]}

Zhao, Dongke ^{[1
]}

Hu, Sheng ^{[3
]}

Mao, Jianwei ^{[2
]}

Mei, Lehe ^{[1
,3
]}

机构：

[1] Zhejiang Univ, Dept Chem & Biol Engn, Hangzhou 310027, Zhejiang, Peoples R China

[2] Zhejiang Univ Sci & Technol, Sinogerman ZEHN Inst Agr Prod Proc, Hangzhou 310023, Zhejiang, Peoples R China

[3] Zhejiang Univ, Ningbo Inst Technol, Dept Biol & Pharmaceut Engn, Ningbo 315100, Zhejiang, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2012年 / 87卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Low molecular weight (LMW) chitosan; beta-Chitin; Antioxidant; Bile acid; Squid pens; RADICAL-SCAVENGING ACTIVITY; ANTIOXIDANT ACTIVITY; CHITINS;

D O I：

10.1016/j.carbpol.2011.10.051

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chitosans were prepared by H2O2 oxidative depolyrnerization from squid pens with low molecular weights (LMW) of 13,025, 7011, 4169, 2242 and 963 Da. The bile acid binding capacities and antioxidant properties of LMW chitosans were studied in vitro. LMW chitosans exhibited stronger bile acid binding capacities than that of chitosan. The scavenging ability of LMW chitosans against DPPH radicals improved with increasing concentration, and EC50 values were below 1.3 mg/mL. The EC50 values of LMW chitosans against hydroxyl radicals ranged from 0.93 to 3.66 mg/mL. All LMW chitosans exhibited a strong ferrous ion chelating effect and reducing power. At 1 mg/mL, the scavenging ability of chitosan-963 towards superoxide radicals was 67.76%. These results indicated that LMW chitosans which have stronger bile acid binding capacity and antioxidant activities may act as potential antioxidants in vitro. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2231 / 2236

页数：6

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