Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]-hexanes by photochemical decomposition of CHF2-pyrazolines

被引：12

作者：

Zheng, Yang ^{[1
]}

Yu, Xinling ^{[1
]}

Lv, Songyang ^{[1
]}

Mykhailiuk, Pavel K. ^{[2
,3
]}

Ma, Qiang ^{[1
]}

Hai, Li ^{[1
]}

Wu, Yong ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Dept Med Chem, Key Lab Drug Targeting,Educ Minist, Chengdu 610041, Sichuan, Peoples R China

[2] Enamine Ltd, Matrosova 23, UA-01103 Kiev, Ukraine

[3] Taras Shevchenko Natl Univ Kyiv, Chem Dept, Volodymyrska 64, UA-01601 Kiev, Ukraine

来源：

RSC ADVANCES | 2018年 / 8卷 / 10期

基金：

中国国家自然科学基金;

关键词：

BIOLOGICAL EVALUATION; DERIVATIVES; DISCOVERY; CYCLOPROPANATION; REARRANGEMENT; FLUORINATION; PYRAZOLINES; CHEMISTRY; INSERTION; NITROGEN;

D O I：

10.1039/c7ra13141k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical synthesis of CHF2-substituted 3-azabicyclo[3.1.0] hexanes was developed for the first time. The key step was photochemical decomposition of CHF2-substituted pyrazolines. This protocol has the advantages of simple operation, and mild conditions, as well as excellent functional group tolerance, giving the desired products in moderate to excellent yields.

引用

页码：5114 / 5118

页数：5

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