Prognostic impact of splenic artery invasion for pancreatic cancer of the body and tail

被引：22

作者：

Fukami, Yasuyuki ^{[1
]}

Kaneoka, Yuji ^{[1
]}

Maeda, Atsuyuki ^{[1
]}

Takayama, Yuichi ^{[1
]}

Onoe, Shunsuke ^{[1
]}

机构：

[1] Ogaki Municipal Hosp, Dept Surg, 4-86 Minaminokawa Cho, Ogaki, Gifu 5038502, Japan

来源：

INTERNATIONAL JOURNAL OF SURGERY | 2016年 / 35卷

关键词：

Pancreatic cancer; Distal pancreatectomy; Splenic artery; Splenic vein; CELIAC AXIS RESECTION; LYMPH-NODE RATIO; DISTAL PANCREATECTOMY; CARCINOMA; ADENOCARCINOMA; PANCREATICODUODENECTOMY; SURVIVAL; SINGLE;

D O I：

10.1016/j.ijsu.2016.09.076

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: The prognostic impact of splenic artery (SA) invasion after resection for pancreatic cancer of the body and tail has not been investigated. The aim of this study was to assess the clinical value of SA invasion for pancreatic cancer of the body and tail. Methods: Between 1993 and 2015, 64 patients who underwent distal pancreatectomy (DP) for histologically confirmed pancreatic ductal adenocarcinoma of the body and tail were included in this study. Clinicopathological prognostic factors for survival were analyzed using a prospectively collected database. Results: Of the 64 study patients, histologic invasion of the SA was confirmed in 23 (35.9%) cases. The prognosis of patients with SA invasion was significantly worse than that of patients with non-SA invasion (median survival: 16.0 versus 34.7 months, p = 0.014). Multivariate analysis indicated that lymph node metastases (risk ratio: 2.817, p = 0.005) and R1 resection (risk ratio: 2.715, p = 0.006) were independently associated with overall survival after DP for pancreatic cancer of the body and tail. In contrast, SA invasion was not extracted as an independent prognostic factor. Conclusions: SA invasion after resection for pancreatic cancer of the body and tail does not have the prognostic impact that surpasses lymph node metastases. (C) 2016 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

引用

页码：64 / 68

页数：5

共 22 条

[1]

[Anonymous], 2009, TNM Classification of Malignant Tumours

[2] Postoperative pancreatic fistula: An international study group (ISGPF) definition [J].

Bassi, C ;

Dervenis, C ;

Butturini, G ;

Fingerhut, A ;

Yeo, C ;

Izbicki, J ;

Neoptolemos, J ;

Sarr, M ;

Traverso, W ;

Buchler, M .

SURGERY, 2005, 138 (01) :8-13

[3] Classification of surgical complications - A new proposal with evaluation in a cohort of 6336 patients and results of a survey [J].

Dindo, D ;

Demartines, N ;

Clavien, PA .

ANNALS OF SURGERY, 2004, 240 (02) :205-213

[4] Evaluation of the Prognostic Factors and Significance of Lymph Node Status in Invasive Ductal Carcinoma of the Body or Tail of the Pancreas [J].

Fujita, Takeo ;

Nakagohri, Toshio ;

Gotohda, Naoto ;

Takahashi, Shinichiro ;

Konishi, Masaru ;

Kojima, Motohiro ;

Kinoshita, Taira .

PANCREAS, 2010, 39 (01) :E48-E54

[5] Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer - Long-term results [J].

Hirano, Satoshi ;

Kondo, Satoshi ;

Hara, Takashi ;

Ambo, Yoshiyasu ;

Tanaka, Eiichi ;

Shichinohe, Toshiaki ;

Suzuki, On ;

Hazama, Kazuaki .

ANNALS OF SURGERY, 2007, 246 (01) :46-51

[6] Invasion of the Splenic Artery Is a Crucial Prognostic Factor in Carcinoma of the Body and Tail of the Pancreas [J].

Kanda, Mitsuro ;

Fujii, Tsutomu ;

Sahin, Tevfik T. ;

Kanzaki, Akiyuki ;

Nagai, Shunji ;

Yamada, Suguru ;

Sugimoto, Hiroyuki ;

Nomoto, Shuji ;

Takeda, Shin ;

Kodera, Yasuhiro ;

Morita, Satoshi ;

Nakao, Akimasa .

ANNALS OF SURGERY, 2010, 251 (03) :483-487

[7] Portal or superior mesenteric vein resection for pancreatic head adenocarcinoma: Prognostic value of the length of venous resection [J].

Kaneoka, Yuji ;

Yamaguchi, Akihiro ;

Isogai, Masatoshi .

SURGERY, 2009, 145 (04) :417-425

[8] Prognostic Factors for Survival After Extended Pancreatectomy for Pancreatic Head Cancer Influence of Resection Margin Status on Survival [J].

Kato, Koichi ;

Yamada, Suguru ;

Sugimoto, Hiroyuki ;

Kanazumi, Naohito ;

Nomoto, Shuji ;

Takeda, Shin ;

Kodera, Yasuhiro ;

Morita, Satoshi ;

Nakao, Akimasa .

PANCREAS, 2009, 38 (06) :605-612

[9]

Kim JH, 2013, PANCREAS, V42, P1316, DOI 10.1097/MPA.0b013e318287c604

[10] Prognostic Significance of Lymph Node Metastases in Pancreatic Head Cancer Treated with Extended Lymphadenectomy: Not Just a Matter of Numbers [J].

Massucco, Paolo ;

Ribero, Dario ;

Sgotto, Enrico ;

Mellano, Alfredo ;

Muratore, Andrea ;

Capussotti, Lorenzo .

ANNALS OF SURGICAL ONCOLOGY, 2009, 16 (12) :3323-3332

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