Acute myeloid leukemia with variant t(8;10;21)

被引：2

作者：

Bacova, Barbora ^{[1
,2
]}

Sobotka, Jiri ^{[3
]}

Kacirkova, Petra ^{[4
]}

Rivnacova, Veronika ^{[1
,2
]}

Zubata, Ivana Karlova ^{[1
,2
]}

Novak, Jan ^{[1
,2
,5
]}

机构：

[1] Charles Univ Prague, Fac Med 3, Dept Haematol, Srobarova 50, Prague 10, Czech Republic

[2] Fac Hosp Kralovske Vinohrady, Srobarova 50, Prague 10, Czech Republic

[3] SPADIA LAB a s, Lab Med Genet, Ostrava, Czech Republic

[4] Fac Hosp Kralovske Vinohrady, Cent Labs, Prague, Czech Republic

[5] Charles Univ Prague, Fac Med 3, Dept Immunol, Ruska 87, Prague 10, Czech Republic

来源：

LEUKEMIA RESEARCH REPORTS | 2022年 / 18卷

关键词：

Acute myeloid leukemia; Cytogenetics; Fluorescence in situ hybridization; t(8 21); CHEMOTHERAPY; PATIENT;

D O I：

10.1016/j.lrr.2022.100350

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The t(8;21)(q22;q22) is one of the most common chromosomal abnormalities in acute myeloid leukemia (AML). Approximately 3-4% of AML cases are associated with additional chromosomal abnormalities. Their impact on the prognosis of the disease remains to be established. Here we report a case of t(8;10;21) AML with mutated c KIT that shared key morphological features with classical t(8;21) leukemias, including the M2 morphology pattern and CD34, HLA-DR phenotype. The 63-year-old female was treated with two inductioncontaining Daunoribicine and Cytarabine and four cycles of intermediate-dose Cytarabine (1.5 g/m2) and achieved longlasting remission.

引用

页数：4

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