Acute myeloid leukemia with variant t(8;10;21)

被引：1
作者：
Bacova, Barbora [1 ,2 ]
Sobotka, Jiri [3 ]
Kacirkova, Petra [4 ]
Rivnacova, Veronika [1 ,2 ]
Zubata, Ivana Karlova [1 ,2 ]
Novak, Jan [1 ,2 ,5 ]
机构：
[1] Charles Univ Prague, Fac Med 3, Dept Haematol, Srobarova 50, Prague 10, Czech Republic
[2] Fac Hosp Kralovske Vinohrady, Srobarova 50, Prague 10, Czech Republic
[3] SPADIA LAB a s, Lab Med Genet, Ostrava, Czech Republic
[4] Fac Hosp Kralovske Vinohrady, Cent Labs, Prague, Czech Republic
[5] Charles Univ Prague, Fac Med 3, Dept Immunol, Ruska 87, Prague 10, Czech Republic
来源：
LEUKEMIA RESEARCH REPORTS | 2022年 / 18卷
关键词：
Acute myeloid leukemia; Cytogenetics; Fluorescence in situ hybridization; t(8 21); CHEMOTHERAPY; PATIENT;
D O I：
10.1016/j.lrr.2022.100350
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The t(8;21)(q22;q22) is one of the most common chromosomal abnormalities in acute myeloid leukemia (AML). Approximately 3-4% of AML cases are associated with additional chromosomal abnormalities. Their impact on the prognosis of the disease remains to be established. Here we report a case of t(8;10;21) AML with mutated c KIT that shared key morphological features with classical t(8;21) leukemias, including the M2 morphology pattern and CD34, HLA-DR phenotype. The 63-year-old female was treated with two inductioncontaining Daunoribicine and Cytarabine and four cycles of intermediate-dose Cytarabine (1.5 g/m2) and achieved longlasting remission.
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页数：4
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