Upregulating of Fas, integrin β4 and P53 and depressing of PC-PLC activity and ROS level in VEC apoptosis by safrole oxide

被引：47

作者：

Zhao, J

Miao, JY

Zhao, BX

Zhang, SL

机构：

[1] Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Peoples R China

[2] Shandong Univ, Inst Organ Chem, Sch Chem & Chem Engn, Jinan 250100, Shangdong, Peoples R China

来源：

FEBS LETTERS | 2005年 / 579卷 / 25期

基金：

中国国家自然科学基金;

关键词：

safrole oxide; apoptosis; mechanism; endothelial cells;

D O I：

10.1016/j.febslet.2005.09.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previously, we found that safrole oxide could trigger vascular endothelial cell (VEC) apoptosis. In this study, to investigate its mechanism to induce apoptosis in VECs, the activities of nitric oxide synthetase and phosphatidylcholine specific phospholipase C, the level of reactive oxygen species and the expressions of Fas, integrin beta 4 and P53 were analyzed. The data showed that safrole oxide induced apoptosis by increasing the expressions of Fas, integrin beta 4 and P53, and depressing the activity of Ca2+-independent phosphatidylcholine-specific phospholipase C and intracellular reactive oxygen species levels in VECs. (c) 2005 Published by Elsevier B.V.

引用

页码：5809 / 5813

页数：5

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