Renin-Angiotensin-Aldosterone System and Migraine: A Systematic Review of Human Studies

被引：7
作者：
Sassi, Karina Lucia Moreira [1 ]
Martins, Lais Bhering [1 ]
de Miranda, Aline Silva [2 ]
Teixeira, Antonio Lucio [1 ]
机构：
[1] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Psychiat & Behav Sci, Neuropsychiat Program, Houston, TX 77030 USA
[2] Fed Univ Minas Gerais UFMG, Inst Biol Sci, Dept Morphol, Belo Horizonte, MG, Brazil
来源：
PROTEIN AND PEPTIDE LETTERS | 2020年 / 27卷 / 06期
关键词：
Renin; angiotensin; aldosterone; migraine; headache; genetics; CORTICAL SPREADING DEPRESSION; II RECEPTOR BLOCKER; CONVERTING-ENZYME; PROPHYLACTIC TREATMENT; POLYMORPHISMS; ACE; PATHOPHYSIOLOGY; TELMISARTAN; ASSOCIATION; HEADACHE;
D O I：
10.2174/0929866527666200129160136
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We carried out a systematic review of the studies evaluating the involvement of RAS in patients with migraine. There is evidence from genetic studies exploring the relation between migraine and RAS-related genes and from clinical trials evaluating the efficacy of Angiotensin II Type 1 (AT1) receptor antagonists and angiotensin converting enzyme inhibitors in migraine prophylaxis. RAS seems to play a role in the pathophysiology of migraine, but more direct evidence is still missing.
引用
收藏
页码：512 / 519
页数：8
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