An improved synthesis of [24-14C]cholic acid, and its application to the synthesis of [14C]SCH 209702 (Syn3).: Synthesis of [2H8]SCH 209702

被引：3

作者：

Ren, Sumei ^{[1
]}

McNamara, Paw ^{[1
]}

Kahairski, Davd ^{[1
]}

机构：

[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2008年 / 51卷 / 5-6期

关键词：

24-(14)C]cholic acid; bile acid; SCH; 209702; Syn3; carbon-14; synthesis;

D O I：

10.1002/jlcr.1509

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient synthesis of [24- (14)C]cholic acid from potassium [(14)C]cyanide has been developed. The key intermediate, 23-chloro-3 alpha, 7 alpha, 12 alpha-triformyloxynorcholane, was synthesized by degradation of triformyl protected cholic acid. Different degradation conditions were explored. The synthesis of [(14)C]SCH 209702 from 23-chloro-3 alpha, 7 alpha, 12 alpha-triformyloxynorcholane and potassium [(14)C]cyanide is described. The synthesis of [(2)H(8)]SCH 209702 from [(2)H(4)]cholic acid is also presented.

引用

页码：231 / 235

页数：5

共 15 条

[11] LABELED BILE-ACIDS .5. DEUTERIUM AND C-13 LABELED CHOLIC, CHENODEOXYCHOLIC AND URSODEOXYCHOLIC ACIDS [J].