DNA virus uncoating

被引：39

作者：

Kilcher, Samuel ^{[1
]}

Mercer, Jason ^{[1
]}

机构：

[1] UCL, MRC Lab Mol Cell Biol, London WC1E 6BT, England

来源：

VIROLOGY | 2015年 / 479卷

基金：

英国医学研究理事会;

关键词：

Virus entry; Endocytosis; Fusion; Viral genome release; Capsid priming; NUCLEAR-PORE COMPLEX; MINOR CAPSID PROTEIN; NF-KAPPA-B; VACCINIA VIRUS; ADENOVIRUS-PROTEINASE; TEGUMENT PROTEIN; POXVIRUS DNA; VIRAL-DNA; IN-VITRO; PAPILLOMAVIRUS INFECTION;

D O I：

10.1016/j.virol.2015.01.024

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Virus genomes are condensed and packaged inside stable proteinaceous capsids that serve to protect them during transit from one cell or host organism, to the next. During virus entry, capsid shells are primed and disassembled in a complex, tightly-regulated, multi-step process termed uncoating. Here we compare the uncoating-programs of DNA viruses of the pox-, herpes-, adeno-, polyoma-, and papillomavirus families. Highlighting the chemical and mechanical cues virus capsids respond to, we review the conformational changes that occur during stepwise disassembly of virus capsids and how these culminate in the release of viral genomes at the right time and cellular location to assure successful replication. (C) 2015 Published by Elsevier Inc.

引用

页码：578 / 590

页数：13

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