A Novel and Efficient Synthesis of Pyrido[1,2-a]-Fused 1,3-Diazaheterocyclic Compounds via a One-Pot Three-Component Reaction

被引：7

作者：

Alizadeh, Abdolali ^{[1
]}

Rezvanian, Atieh ^{[1
]}

机构：

[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

HELVETICA CHIMICA ACTA | 2012年 / 95卷 / 01期

关键词：

Diamines; Ketene dithioacetals; nitro-; Itaconic anhydride; Pyrido[1; 2-a]-fused compounds; Multicomponent reactions;

D O I：

10.1002/hlca.201100274

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient one-pot synthesis of pyrido[1,2-a]-fused 1,3-diazaheterocyclic compounds by three-component reaction of diamine, nitroketene dithioacetal (=1,1-bis(methylsulfanyl)-2-nitroethene), and electron-poor itaconic anhydride (=2-methylidenesuccinic anhydride=2-methylidenebutanedioic anhydride) in aqueous EtOH is reported. This protocol has the advantages of easiness, higher yields, and shorter reaction times. The structures were corroborated spectroscopically (IR, 1H- and 13C-NMR, and EI-MS) and by elemental analyses. A plausible mechanism for this type of cyclization is proposed (Scheme 2).

引用

页码：152 / 156

页数：5

共 4 条

[1] Practical and Novel One-Pot Protocol for the Synthesis of Highly Functionalized Pyridinols and Pyrido[1,2-a]-Fused 1,3-Diazaheterocycles [J].