Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology

被引：217

作者：

Butler, AA ^{[1
]}

Yakar, S ^{[1
]}

Gewolb, IH ^{[1
]}

Karas, M ^{[1
]}

Okubo, Y ^{[1
]}

LeRoith, D ^{[1
]}

机构：

[1] NIDDKD, Sect Mol & Cellular Physiol, Diabet Branch, NIH, Bethesda, MD 20892 USA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1998年 / 121卷 / 01期

关键词：

insulin-like growth factor-I receptor; signal transduction; physiology; cell biology;

D O I：

10.1016/S0305-0491(98)10106-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of IGF-I and IGF-II. The IGFs play a critical role in promoting development, stimulating growth and organogenesis via mitogenic, antiapoptotic and chemotactic activity. Recent research has focused on the events that occur intracellularly upon receptor activation. Several pathways have been shown to be important. The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. This review outlines some of the signalling pathways believed to be important in converting IGF-IR activation into changes in cell behavior and metabolism. (C) 1998 Published by Elsevier Science inc. All rights reserved.

引用

页码：19 / 26

页数：8

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