Model of interaction of the IL-1 receptor accessory protein IL-1RAcP with the IL-1β/IL-1RI complex

被引：62

作者：

Casadio, R

Frigimelica, E

Bossù, P

Neumann, D

Martin, MU

Tagliabue, A

Boraschi, D

机构：

[1] Natl Res Council, IMD, Immunobiol Lab, I-56124 Pisa, Italy

[2] ALTA Srl, I-53035 Monteriggioni, Italy

[3] Med Hsch Hannover, D-30623 Hannover, Germany

[4] Dompe SpA, I-67100 Laquila, Italy

[5] Univ Bologna, Lab Biocomp, Bologna, Italy

来源：

FEBS LETTERS | 2001年 / 499卷 / 1-2期

关键词：

interleukin; 1; receptor chain; accessory protein; molecular modeling;

D O I：

10.1016/S0014-5793(01)02515-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A preliminary model has been calculated for the activating interaction of the interleukin 1 receptor (IL-1R) accessory protein IL-1RAcP with the ligand/receptor complex IL-I beta /IL-1R(1). First, IL-1RAcP was modeled on the crystal structure of IL-1R(1) bound to IL-1 beta. Then, the IL-1RAcP model was docked using specific programs to the crystal structure of the IL-1 beta /IL-1R(1) complex. Two types Of models were predicted, with comparable probability, Experimental data obtained with the use of IL-1 beta peptides and antibodies, and with mutated IL-1 beta proteins, support the BACK model, in which IL-1RAcP establishes contacts with the bark of IL-1R(1) wrapped around IL-1 beta. (C) 2001 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.

引用

页码：65 / 68

页数：4

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