Measurement of trace levels of antibiotics in river water using on-line enrichment and triple-quadrupole LC-MS/MS

被引：185

作者：

Quoc Tuc Dinh ^{[1
]}

Alliot, Fabrice ^{[1
]}

Moreau-Guigon, Elodie ^{[1
]}

Eurin, Joelle ^{[1
]}

Chevreuil, Marc ^{[1
]}

Labadie, Pierre

机构：

[1] Univ Paris 06, Lab Hydrol & Environm EPHE, UMR Sisyphe 7619, F-75252 Paris 05, France

来源：

TALANTA | 2011年 / 85卷 / 03期

关键词：

Antibiotics; On-line solid phase extraction; Liquid chromatography-tandem mass spectrometry; River water; TANDEM MASS-SPECTROMETRY; SOLID-PHASE EXTRACTION; VETERINARY ANTIBIOTICS; ANTIBACTERIAL AGENTS; AQUATIC ENVIRONMENT; RELIABLE QUANTIFICATION; POTENTIAL IMPACT; TREATMENT PLANTS; MANGROVE AREAS; SURFACE-WATER;

D O I：

10.1016/j.talanta.2011.05.013

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This study presents the development of an automated on-line solid phase extraction (SPE)-liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of 23 antibiotics in environmental water samples. After optimisation of LC-MS/MS conditions, SPE parameters such as sorbent type, sample pH or sample volume were optimised. Antibiotic recoveries ranged from 64% to 98% and compared favourably with those achieved using off-line SPE. Limits of detection were in the range 0.5-13.7 ng L(-1). This on-line SPE-LC-MS/MS procedure was applied to the analysis of water samples taken in three rivers within the Seine River basin, near Paris (France). The obtained results revealed the occurrence of 12 antibiotics, including tylosin, erythromycin, tetracycline, amoxicillin, trimethoprim, sulfamethoxazole, oxolinic acid, flumequine, norfloxacin, ciprofloxacin, ofloxacin, and vancomycin (2-1435 ng L(-1)). (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1238 / 1245

页数：8

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