Effect of Noopept on Dynamics of Intracellular Calcium in Neurons of Cultured Rat Hippocampal Slices

被引:2
作者
Kolbaev, S. N. [1 ]
Aleksandrova, O. P. [1 ]
Sharonova, I. N. [1 ]
Skrebitsky, V. G. [1 ]
机构
[1] Res Ctr Neurol, Moscow, Russia
基金
俄罗斯科学基金会;
关键词
hippocampus; Noopept; intracellular calcium; fluorescence; DIPEPTIDE NOOPEPT;
D O I
10.1007/s10517-018-3983-3
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
A neuroprotective and nootropic drug Noopept increased the frequency of spontaneous calcium transients in neurons of CA1 radial layer in cultured rat hippocampal slices. In contrast, the drug exerted no significant effect on intracellular calcium concentration and its dynamics in neurons of hippocampal CA1 pyramidal layer.
引用
收藏
页码:330 / 333
页数:4
相关论文
共 15 条
[1]   The nicotinic acetylcholine receptor subtypes and their function in the hippocarnpus and cerebral cortex [J].
Alkondon, M ;
Albuquerque, EX .
ACETYLCHOLINE IN THE CEREBRAL CORTEX, 2004, 145 :109-120
[2]  
Andreeva NA, 2000, B EXP BIOL MED+, V130, P969
[3]   Dipeptide preparation Noopept prevents scopolamine-induced deficit of spatial memory in BALB/c mice [J].
Belnik, A. P. ;
Ostrovskaya, R. U. ;
Poletaeva, I. I. .
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2007, 143 (04) :431-433
[4]  
Bochkaryov VK, 2008, ZH NEVROL PSIKHIATR, V108, P47
[5]   Selective blockade of Ca2+ permeable AMPA receptors in CA1 area of rat hippocampus [J].
Buldakova, S. L. ;
Kim, K. K. ;
Tikhonov, D. B. ;
Magazanik, L. G. .
NEUROSCIENCE, 2007, 144 (01) :88-99
[6]   Imaging Calcium in Neurons [J].
Grienberger, Christine ;
Konnerth, Arthur .
NEURON, 2012, 73 (05) :862-885
[7]   Neuroprotective and Nootropic Drug Noopept Rescues α-Synuclein Amyloid Cytotoxicity [J].
Jia, Xueen ;
Gharibyani, Anna L. ;
Ohman, Anders ;
Liu, Yonggang ;
Olofsson, Anders ;
Morozova-Roche, Ludmilla A. .
JOURNAL OF MOLECULAR BIOLOGY, 2011, 414 (05) :699-712
[8]   Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells [J].
Kondratenko, Rodion V. ;
Derevyagin, Vladimir I. ;
Skrebitsky, Vladimir G. .
NEUROSCIENCE LETTERS, 2010, 476 (02) :70-73
[9]  
Ostrovskaya R. U., 2001, Eksperimental'naya i Klinicheskaya Farmakologiya, V64, P11
[10]  
Ostrovskaya R. U., 2002, Eksperimental'naya i Klinicheskaya Farmakologiya, V65, P66