Physical activity and gain in abdominal adiposity and body weight: prospective cohort study in 288,498 men and women

被引：94

作者：

Ekelund, Ulf ^{[1
]}

Besson, Herve ^{[1
]}

Luan, Jian'an ^{[1
]}

May, Anne M. ^{[2
,3
]}

Sharp, Stephen J. ^{[1
]}

Brage, Soren ^{[1
]}

Travier, Noemie ^{[4
]}

Agudo, Antonio ^{[4
]}

Slimani, Nadia ^{[5
]}

Rinaldi, Sabina ^{[5
]}

Jenab, Mazda ^{[6
]}

Norat, Teresa ^{[7
]}

Mouw, Traci ^{[7
]}

Rohrmann, Sabine ^{[8
]}

Kaaks, Rudolf ^{[8
]}

Bergmann, Manuela M. ^{[9
]}

Boeing, Heiner ^{[9
]}

Clavel-Chapelon, Francoise ^{[10
]}

Boutron-Ruault, Marie-Christine ^{[10
]}

Overvad, Kim ^{[11
,13
]}

Jakobsen, Marianne Uhre ^{[12
]}

Johnsen, Nina Fons ^{[14
]}

Halkjaer, Jytte ^{[14
]}

Gonzalez, Carlos A. ^{[4
]}

Rodriguez, Laudina ^{[15
]}

Sanchez, Maria Jose ^{[16
,17
]}

Arriola, Larraitz ^{[18
]}

Barricarte, Aurelio ^{[19
]}

Navarro, Carmen ^{[20
]}

Key, Timothy J. ^{[21
]}

Spencer, Elisabeth A. ^{[21
]}

Orfanos, Philippos ^{[22
,23
]}

Naska, Androniki ^{[22
,23
]}

Trichopoulou, Antonia ^{[22
,23
]}

Manjer, Jonas

Lund, Eiliv ^{[24
]}

Palli, Dominico ^{[25
]}

Pala, Valeria ^{[26
]}

Vineis, Paolo ^{[8
,27
]}

Mattiello, Amalia ^{[28
]}

Tumino, Rosario ^{[29
,30
]}

Bueno-de-Mesquita, H. Bas ^{[3
]}

van den Berg, Saskia W. ^{[3
]}

Odysseos, Andreani D. ^{[31
]}

Riboli, Elio ^{[7
]}

Wareham, Nicolas J. ^{[1
]}

Peeters, Petra H. ^{[2
,7
]}

机构：

[1] Inst Metab Sci, Med Res Council, Epidemiol Unit, Cambridge, England

[2] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[3] Natl Inst Publ Hlth & Environm, Ctr Nutr & Hlth, Bilthoven, Netherlands

[4] Catalan Inst Oncol IDIBELL, Unit Nutr Environm & Canc, Barcelona, Spain

[5] Int Agcy Res Canc, Dietary Exposure Assessment Grp, Lyon, France

[6] Int Agcy Res Canc, Lifestyle Environm & Canc Grp, Lyon, France

[7] Imperial Coll, Sch Publ Hlth & Primary Care, London, England

[8] German Canc Res Ctr, Div Canc Epidemiol, Nutr Epidemiol Unit, Heidelberg, Germany

[9] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[10] Univ Paris South, Inst Natl Sante Rech Med, Inst Gustave Roussy, EA4045,ERI20, Villejuif, France

[11] Aalborg Hosp, Dept Cardiol, Aalborg, Denmark

[12] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[13] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[14] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[15] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[16] Andalusian Sch Publ Hlth, Granada Canc Registry, Granada, Spain

[17] CIBER Epidemiol & Salud Publ CIBERESP, Granada, Spain

[18] Basque Govt, Publ Hlth Dept Gipuzkoa, CIBERESP, San Sebastian, Spain

[19] Inst Publ Hlth Navarra, Epidemiol Prevent & Promot Hlth Serv, Pamplona, Spain

[20] Murcia Hlth Council, CIBERESP, Epidemiol Dept, Murcia, Spain

[21] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[22] Hellen Hlth Fdn, Athens, Greece

[23] Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, Athens, Greece

[24] Univ Tromso, Inst Community Med, Tromso, Norway

[25] Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy

[26] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[27] Univ Turin, Dept Biomed Sci & Human Oncol, Turin, Italy

[28] Federico II Univ Naples, Dept Clin & Expt Med, Naples, Italy

[29] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy

[30] Civile MP Arezzo Hosp, Dept Oncol, Histopathol Unit, Ragusa, Italy

[31] EPOS IASIS, Res & Dev, Biomed Res, Nicosia, Cyprus

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2011年 / 93卷 / 04期

基金：

英国医学研究理事会;

关键词：

WAIST CIRCUMFERENCE; HEART-RATE; OBESITY; CANCER; RISK; PARTICIPANTS; QUESTIONNAIRE; ACCELEROMETRY; ASSOCIATION; OVERWEIGHT;

D O I：

10.3945/ajcn.110.006593

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: The protective effect of physical activity (PA) on abdominal adiposity is unclear. Objective: We examined whether PA independently predicted gains in body weight and abdominal adiposity. Design: In a prospective cohort study [the EPIC (European Prospective Investigation into Cancer and Nutrition)], we followed 84,511 men and 203,987 women for 5.1 y. PA was assessed by a validated questionnaire, and individuals were categorized into 4 groups (inactive, moderately inactive, moderately active, and active). Body weight and waist circumference were measured at baseline and self-reported at follow-up. We used multilevel mixed-effects linear regression models and stratified our analyses by sex with adjustments for age, smoking status, alcohol consumption, educational level, total energy intake, duration of follow-up, baseline body weight, change in body weight, and waist circumference (when applicable). Results: PA significantly predicted a lower waist circumference (in cm) in men (beta = -0.045; 95% CI: -0.057, -0.034) and in women (beta = -0.035; 95% CI: -0.056, -0.015) independent of baseline body weight, baseline waist circumference, and other confounding factors. The magnitude of associations was materially unchanged after adjustment for change in body weight. PA was not significantly associated with annual weight gain (in kg) in men (beta = -0.008; 95% CI: -0.02, 0.003) and women (beta = -0.01; 95% CI: -0.02, 0.0006). The odds of becoming obese were reduced by 7% (P < 0.001) and 10% (P < 0.001) for a one-category difference in baseline PA in men and women, respectively. Conclusion: Our results suggest that a higher level of PA reduces abdominal adiposity independent of baseline and changes in body weight and is thus a useful strategy for preventing chronic diseases and premature deaths. Am J Clin Nutr 2011;93:826-35.

引用

页码：826 / 835

页数：10

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