Molecular Basis of Macrolide, Triamilide, and Lincosamide Resistance in Pasteurella multocida from Bovine Respiratory Disease

被引：53

作者：

Kadlec, Kristina ^{[1
]}

Michael, Geovana Brenner ^{[1
,2
]}

Sweeney, Michael T. ^{[3
]}

Brzuszkiewicz, Elzbieta ^{[2
]}

Liesegang, Heiko ^{[2
]}

Daniel, Rolf ^{[2
]}

Watts, Jeffrey L. ^{[3
]}

Schwarz, Stefan ^{[1
]}

机构：

[1] Friedrich Loeffler Inst FLI, Inst Farm Anim Genet, D-31535 Neustadt, Germany

[2] Univ Gottingen, Gottingen Genom Lab, Inst Microbiol & Genet, Gottingen, Germany

[3] Pfizer Anim Hlth, Kalamazoo, MI USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 05期

关键词：

COMPLETE NUCLEOTIDE-SEQUENCE; TETRACYCLINE RESISTANCE; PLASMID; SUSCEPTIBILITY; TULATHROMYCIN; DETERMINANT; MANNHEIMIA; SPREAD; BORNE; SWINE;

D O I：

10.1128/AAC.00092-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mechanism of macrolide-triamilide resistance in Pasteurella multocida has been unknown. During whole-genome sequencing of a multiresistant bovine P. multocida isolate, three new resistance genes, the rRNA methylase gene erm(42), the macrolide transporter gene msr(E), and the macrolide phosphotransferase gene mph(E), were detected. The three genes were PCR amplified, cloned into suitable plasmid vectors, and shown to confer either macrolide-lincosamide resistance [erm(42)] or macrolide-triamilide resistance [msr(E)=mph(E)] in macrolide-susceptible Escherichia coli and P. multocida hosts.

引用

页码：2475 / 2477

页数：3

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