Concise synthesis of the pyruvic acid acetal containing pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O156

被引：5
|
作者：
Si, Anshupriya [1 ]
Misra, Anup Kumar [1 ]
机构：
[1] Bose Inst, Div Mol Med, P-1-12,CIT Scheme 7M, Kolkata 700054, India
来源：
RSC ADVANCES | 2017年 / 7卷 / 79期
关键词：
EFFICIENT; GLYCOSYLATION; DIARRHEA; TRISACCHARIDE; INFECTIONS; HCLO4-SIO2; BACTERIA; VACCINES; DISEASE; SILICA;
D O I：
10.1039/c7ra07567g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An elegant convergent synthetic strategy has been developed for the preparation of the 4,6-O-(R)-pyruvate acetal containing pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O156 using stereoselective [2 + 3] block glycosylation. Stereoselective 1,2-cis glycosylation of the judiciously functionalized monosaccharide intermediates led to the formation of the desired pentasaccharide in satisfactory yield.
引用
收藏
页码：49903 / 49909
页数：7
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