IL-21 and IL-21 receptor in the immunopathogenesis of multiple sclerosis

被引：35

作者：

Ghalamfarsa, Ghasem ^{[1
]}

Mahmoudi, Mahmoud ^{[2
]}

Mohammadnia-Afrouzi, Mousa ^{[3
]}

Yazdani, Yaghoub ^{[4
,5
]}

Anvari, Enayat ^{[6
]}

Hadinia, Abolghasem ^{[1
]}

Ghanbari, Amir ^{[1
]}

Setayesh, Maryam ^{[7
]}

Yousefi, Mehdi ^{[8
,9
]}

Jadidi-Niaragh, Farhad ^{[10
]}

机构：

[1] Yasuj Univ Med Sci, Cellular & Mol Res Ctr, Yasuj, Iran

[2] Mashhad Univ Med Sci, Sch Med, Dept Immunol & Allergy, Immunol Res Ctr, Mashhad, Iran

[3] Babol Univ Med Sci, Sch Med, Dept Immunol & Microbiol, Babol Sar, Iran

[4] Golestan Univ Med Sci, Infect Dis Res Ctr, Gorgan, Iran

[5] Golestan Univ Med Sci, Lab Sci Res Ctr, Gorgan, Iran

[6] Ilam Univ Med Sci, Fac Med, Dept Physiol, Ilam, Iran

[7] Shiraz Univ, Sch Sci, Dept Biol, Shiraz, Iran

[8] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[9] Tabriz Univ Med Sci, Dept Immunol, Fac Med, Tabriz, Iran

[10] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran 14155, Iran

来源：

JOURNAL OF IMMUNOTOXICOLOGY | 2016年 / 13卷 / 03期

关键词：

Interleukin (IL)-21; IL-21; receptor; multiple sclerosis; pathogenesis; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; REGULATORY T-CELLS; B-CELLS; NEUROMYELITIS-OPTICA; TH17; CELLS; NK CELLS; DIFFERENT SUBSETS; EFFECTOR FUNCTION; HELPER-CELLS;

D O I：

10.3109/1547691X.2015.1089343

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Cytokines are considered important factors in the modulation of various immune responses. Among them, interleukin (IL)-21 is one of the major immune modulators, adjusting various immune responses by affecting various immune cells. It has been suggested that IL-21 may enhance autoimmunity through different mechanisms, such as development and activation of helper T (T-H)-17 and follicular helper T (T-FH) cells, activation of natural killer (NK) cells, enhancing B-cell differentiation and antibody secretion and suppression of regulatory T (T-reg) cells. Moreover, IL-21 has also been suggested to be an inducer of autoimmunity when following treatment of MS patients with some therapeutics such as alemtuzumab. This review will seek to clarify the precise role of IL-21/IL-21R in the pathogenesis of MS and, in its animal model, experimental autoimmune encephalomyelitis (EAE).

引用

页码：274 / 285

页数：12

共 120 条

[41] Regulatory T cells in chronic lymphocytic leukemia: implication for immunotherapeutic interventions [J].

Jadidi-Niaragh, Farhad ;

Ghalamfarsa, Ghasem ;

Yousefi, Mehdi ;

Tabrizi, Mina Hajifaraj ;

Shokri, Fazel .

TUMOR BIOLOGY, 2013, 34 (04) :2031-2039

[42] Downregulation of IL-17-producing T cells is associated with regulatory T cell expansion and disease progression in chronic lymphocytic leukemia [J].

Jadidi-Niaragh, Farhad ;

Ghalamfarsa, Ghasem ;

Memarian, Ali ;

Asgarian-Omran, Hossein ;

Razavi, Seyed Mohsen ;

Sarrafnejad, Abdolfattah ;

Shokri, Fazel .

TUMOR BIOLOGY, 2013, 34 (02) :929-940

[43] Increased Frequency of CD8+ and CD4+ Regulatory T Cells in Chronic Lymphocytic Leukemia: Association with Disease Progression [J].

Jadidi-Niaragh, Farhad ;

Yousefi, Mehdi ;

Memarian, Ali ;

Hojjat-Farsangi, Mohammad ;

Khoshnoodi, Jalal ;

Razavi, Seyed Mohsen ;

Jeddi-Tehrani, Mahmood ;

Shokri, Fazel .

CANCER INVESTIGATION, 2013, 31 (02) :121-131

[44] The deviated balance between regulatory T cell and Th17 in autoimmunity [J].

Jadidi-Niaragh, Farhad ;

Mirshafiey, Abbas .

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2012, 34 (05) :727-739

[45] Regulatory T-cell as orchestra leader in immunosuppression process of multiple sclerosis [J].

Jadidi-Niaragh, Farhad ;

Mirshafiey, Abbas .

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2011, 33 (03) :545-567

[46] Therapeutic Approach to Multiple Sclerosis by Novel Oral Drugs [J].

Jadidi-Niaragh, Farhad ;

Mirshafiey, Abbas .

RECENT PATENTS ON INFLAMMATION & ALLERGY DRUG DISCOVERY, 2011, 5 (01) :66-80

[47] Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis [J].

Jadidi-Niaragh, Farhad ;

Mirshafiey, Abbas .

NEUROPHARMACOLOGY, 2010, 59 (03) :180-189

[48] CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death [J].

Janssen, EM ;

Droin, NM ;

Lemmens, EE ;

Pinkoski, MJ ;

Bensinger, SJ ;

Ehst, BD ;

Griffith, TS ;

Green, DR ;

Schoenberger, SP .

NATURE, 2005, 434 (7029) :88-93

[49] IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H) [J].

Jones, Joanne L. ;

Phuah, Chia-Ling ;

Cox, Amanda L. ;

Thompson, Sara A. ;

Ban, Maria ;

Shawcross, Jacqueline ;

Walton, Amie ;

Sawcer, Stephen J. ;

Compston, Alastair ;

Coles, Alasdair J. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (07) :2052-2061

[50] IL-21 limits NK cell responses and promotes antigen-specific T cell activation: A mediator of the transition from innate to adaptive immunity [J].

Kasaian, MT ;

Whitters, MJ ;

Carter, LL ;

Lowe, LD ;

Jussif, JM ;

Deng, BJ ;

Johnson, KA ;

Witek, JS ;

Senices, M ;

Konz, RF ;

Wurster, AL ;

Donaldson, DD ;

Collins, M ;

Young, DA ;

Grusby, MJ .

IMMUNITY, 2002, 16 (04) :559-569

← 1 2 3 4 5 6 7 8 9 10 →