IL-21 and IL-21 receptor in the immunopathogenesis of multiple sclerosis

被引：35

作者：

Ghalamfarsa, Ghasem ^{[1
]}

Mahmoudi, Mahmoud ^{[2
]}

Mohammadnia-Afrouzi, Mousa ^{[3
]}

Yazdani, Yaghoub ^{[4
,5
]}

Anvari, Enayat ^{[6
]}

Hadinia, Abolghasem ^{[1
]}

Ghanbari, Amir ^{[1
]}

Setayesh, Maryam ^{[7
]}

Yousefi, Mehdi ^{[8
,9
]}

Jadidi-Niaragh, Farhad ^{[10
]}

机构：

[1] Yasuj Univ Med Sci, Cellular & Mol Res Ctr, Yasuj, Iran

[2] Mashhad Univ Med Sci, Sch Med, Dept Immunol & Allergy, Immunol Res Ctr, Mashhad, Iran

[3] Babol Univ Med Sci, Sch Med, Dept Immunol & Microbiol, Babol Sar, Iran

[4] Golestan Univ Med Sci, Infect Dis Res Ctr, Gorgan, Iran

[5] Golestan Univ Med Sci, Lab Sci Res Ctr, Gorgan, Iran

[6] Ilam Univ Med Sci, Fac Med, Dept Physiol, Ilam, Iran

[7] Shiraz Univ, Sch Sci, Dept Biol, Shiraz, Iran

[8] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[9] Tabriz Univ Med Sci, Dept Immunol, Fac Med, Tabriz, Iran

[10] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran 14155, Iran

来源：

JOURNAL OF IMMUNOTOXICOLOGY | 2016年 / 13卷 / 03期

关键词：

Interleukin (IL)-21; IL-21; receptor; multiple sclerosis; pathogenesis; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; REGULATORY T-CELLS; B-CELLS; NEUROMYELITIS-OPTICA; TH17; CELLS; NK CELLS; DIFFERENT SUBSETS; EFFECTOR FUNCTION; HELPER-CELLS;

D O I：

10.3109/1547691X.2015.1089343

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Cytokines are considered important factors in the modulation of various immune responses. Among them, interleukin (IL)-21 is one of the major immune modulators, adjusting various immune responses by affecting various immune cells. It has been suggested that IL-21 may enhance autoimmunity through different mechanisms, such as development and activation of helper T (T-H)-17 and follicular helper T (T-FH) cells, activation of natural killer (NK) cells, enhancing B-cell differentiation and antibody secretion and suppression of regulatory T (T-reg) cells. Moreover, IL-21 has also been suggested to be an inducer of autoimmunity when following treatment of MS patients with some therapeutics such as alemtuzumab. This review will seek to clarify the precise role of IL-21/IL-21R in the pathogenesis of MS and, in its animal model, experimental autoimmune encephalomyelitis (EAE).

引用

页码：274 / 285

页数：12

共 120 条

[1] Impaired Autoimmune T Helper 17 Cell Responses Following DNA Vaccination against Rat Experimental Autoimmune Encephalomyelitis [J].

Andersson, Asa ;

Isaksson, Magnus ;

Wefer, Judit ;

Norling, Anna ;

Flores-Morales, Amilcar ;

Rorsman, Fredrik ;

Kampe, Olle ;

Harris, Robert A. ;

Lobell, Anna .

PLOS ONE, 2008, 3 (11)

[2] Th17 Cells in Immunopathogenesis and treatment of rheumatoid arthritis [J].

Azizi, Gholamreza ;

Jadidi-Niaragh, Farhad ;

Mirshafiey, Abbas .

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2013, 16 (03) :243-253

[3] Neuroinflamrnation and brain functional disconnection in Alzheimer's disease [J].

Baglio, Francesca ;

Saresella, Marina ;

Preti, Maria Giulia ;

Cabinio, Monia ;

Griffanti, Ludovica ;

Marventano, Ivana ;

Piancone, Federica ;

Calabrese, Elena ;

Nemni, Raffaello ;

Clerici, Mario .

FRONTIERS IN AGING NEUROSCIENCE, 2013, 5

[4] Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responses [J].

Barker, Brianne R. ;

Gladstone, Michael N. ;

Gillard, Geoffrey O. ;

Panas, Michael W. ;

Letvin, Norman L. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (11) :3085-3096

[5] The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells [J].

Bauquet, Aurelie T. ;

Jin, Hulin ;

Paterson, Alison M. ;

Mitsdoerffer, Meike ;

Ho, I-Cheng ;

Sharpe, Arlene H. ;

Kuchroo, Vijay K. .

NATURE IMMUNOLOGY, 2009, 10 (02) :167-175

[6] IL-21 induces the functional maturation of murine NK cells [J].

Brady, J ;

Hayakawa, Y ;

Smyth, MJ ;

Nutt, SL .

JOURNAL OF IMMUNOLOGY, 2004, 172 (04) :2048-2058

[7] Interleukin-21 inhibits dendritic cell-mediated t cell activation and induction of contact hypersensitivity in vivo [J].

Brandt, K ;

Bulfone-Paus, S ;

Jenckel, A ;

Foster, DC ;

Paus, R ;

Rückert, R .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 121 (06) :1379-1382

[8] Ultraviolet B Light Attenuates the Systemic Immune Response in Central Nervous System Autoimmunity [J].

Breuer, Johanna ;

Schwab, Nicholas ;

Schneider-Hohendorf, Tilman ;

Marziniak, Martin ;

Mohan, Hema ;

Bhatia, Urvashi ;

Gross, Catharina C. ;

Clausen, Bjoern E. ;

Weishaupt, Carsten ;

Luger, Thomas A. ;

Meuth, Sven G. ;

Loser, Karin ;

Wiendl, Heinz .

ANNALS OF NEUROLOGY, 2014, 75 (05) :739-758

[9] Alemtuzumab: evidence for its potential in relapsing-remitting multiple sclerosis [J].

Brown, J. William L. ;

Coles, Alasdair J. .

DRUG DESIGN DEVELOPMENT AND THERAPY, 2013, 7 :131-138

[10] The role of natural killer cells in multiple sclerosis and their therapeutic implications [J].

Chanvillard, Coralie ;

Jacolik, Raymond F. ;

Infante-Duarte, Carmen ;

Nayak, Ramesh C. .

FRONTIERS IN IMMUNOLOGY, 2013, 4

← 1 2 3 4 5 6 7 8 9 10 →