Urinary bladder adenocarcinoma arising in a spina bifida patient

被引:4
作者
Bitar, Mireille [1 ]
Mandel, Edmund
Kirschenbaum, Alexander M.
Unger, Pamela D.
机构
[1] Mt Sinai Hosp, Mt Sinai Sch Med, Dept Pathol, New York, NY 10029 USA
[2] Mt Sinai Hosp, Mt Sinai Sch Med, Dept Urol, New York, NY 10029 USA
关键词
urinary bladder adenocarcinoma; intestinal metaplasia of bladder; neurogenic bladder; spina bifida;
D O I
10.1016/j.anndiagpath.2006.06.002
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Urinary bladder adenocarcinomas are rare malignancies accounting for approximately 2.5% of all urothelial neoplasms. Intestinal metaplasia of the urothelium indicates the presence of intestinal-type goblet cells and was generally observed to coexist with or to precede the diagnosis of bladder adenocarcinomas. Controversy continues of whether intestinal metaplasia is an acquired precancerous lesion, secondary to different insults to The urothelium, or a concomitant lesion in glandular carcinogenesis. Patients with neurogenic bladders are particularly at risk for developing bladder cancer, mostly squamous cell carcinoma and rarely adenocarcinoma. In these patients, chronic irritation of the uroth churn as well as long-term indwelling urinary catheters were the most significant risk factors. Spina bifida is a congenital developmental abnormality that may result in neurogenic bladder. There is only. one previously reported case of urothelial carcinoma with associated squamous metaplasia of the bladder occurring in a spina bifida patient. We report the first case of bladder adenocarcinoma associated with intestinal metaplasia occurring in a spina bifida occulta patient. The patient had a complicated clinical course and suffered recurrent urinary tract infections, renal calculi, and urinary incontinence and was anaged.with intermittent as well as indwelling catheterization. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:453 / 456
页数:4
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