A human colliculus-pulvinar-amygdala pathway encodes negative emotion

被引：47

作者：

Kragel, Philip A. ^{[1
,2
,3
,9
]}

Ceko, Marta ^{[1
]}

Theriault, Jordan ^{[4
]}

Chen, Danlei ^{[4
]}

Satpute, Ajay B. ^{[4
,5
]}

Wald, Lawrence W. ^{[5
,6
]}

Lindquist, Martin A. ^{[7
]}

Barrett, Lisa Feldman ^{[5
,6
]}

Wager, Tor D. ^{[1
,8
]}

机构：

[1] Univ Colorado Boulder, Inst Cognit Sci, Boulder, CO 80309 USA

[2] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA

[3] Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA

[4] Northeastern Univ, Dept Psychol, Boston, MA 02115 USA

[5] Athinoula A Martinos Ctr Biomed Imaging, Boston, MA 02129 USA

[6] Harvard Med Sch, Boston, MA 02129 USA

[7] Johns Hopkins Univ, Dept Biostat, Baltimore, MD 21205 USA

[8] Dartmouth Coll, Dept Psychol & Brain Sci, Hanover, NH 03755 USA

[9] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA

来源：

NEURON | 2021年 / 109卷 / 15期

基金：

美国国家卫生研究院;

关键词：

FUNCTIONAL CONNECTIVITY; SUPERIOR COLLICULUS; CORTEX; ORGANIZATION; UNPLEASANTNESS; REPRESENTATION; PARCELLATION; INFORMATION; VARIABILITY; THALAMUS;

D O I：

10.1016/j.neuron.2021.06.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Animals must rapidly respond to threats to survive. In rodents, threat-related signals are processed through a subcortical pathway from the superior colliculus to the amygdala, a putative "low road"to affective behavior. This pathway has not been well characterized in humans. We developed a novel pathway identification framework that uses pattern recognition to identify connected neural populations and optimize measurement of inter-region connectivity. We first verified that the model identifies known thalamocortical pathways with high sensitivity and specificity in 7 T (n = 56) and 3 T (n = 48) fMRI experiments. Then we identified a human functional superior colliculus-pulvinar-amygdala pathway. Activity in this pathway encodes the intensity of normative emotional responses to negative images and sounds but not pleasant images or painful stimuli. These results provide a functional description of a human "low road"pathway selective for negative exteroceptive events and demonstrate a promising method for characterizing human functional brain pathways.

引用

页码：2404 / +

页数：15

共 89 条

[1] Deconstructing white matter connectivity of human amygdala nuclei with thalamus and cortex subdivisions in vivo [J].