Mutated variant of Candida antarctica lipase B in (S)-selective dynamic kinetic resolution of secondary alcohols

被引：36

作者：

Engstrom, Karin ^{[1
]}

Vallin, Michaela ^{[2
]}

Syren, Per-Olof ^{[2
]}

Hult, Karl ^{[2
]}

Backvall, Jan-E. ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

[2] AlbaNova Univ Ctr, Royal Inst Technol KTH, Sch Biotechnol, Dept Biochem, SE-10691 Stockholm, Sweden

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 01期

基金：

瑞典研究理事会;

关键词：

RATIONAL REDESIGN; ENANTIOSELECTIVITY; CATALYSIS; MECHANISM;

D O I：

10.1039/c0ob00748j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An (S)-selective dynamic kinetic resolution of secondary alcohols, employing a mutated variant of Candida antarctica lipase B (CalB) gave products in 84-88% yield and in 90-97% ee.

引用

页码：81 / 82

页数：2

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