In-vivo light dosimetry for HPPH-mediated pleural PDTimage not open

被引：13

作者：

Dimofte, Andreea ^{[1
]}

Zhu, Timothy C. ^{[1
]}

Finlay, Jarod C. ^{[1
]}

Cullighan, Melissa ^{[2
]}

Edmonds, Christine E. ^{[1
]}

Friedberg, Joseph S. ^{[2
]}

Cengel, Keith ^{[1
]}

Hahn, Stephen M. ^{[1
]}

机构：

[1] Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Surg, Philadelphia, PA 19104 USA

来源：

OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XIX | 2010年 / 7551卷

关键词：

Light dosimetry; photodynamic therapy; Photofrin;

D O I：

10.1117/12.851514

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study examines the light fluence (rate) delivered to patients undergoing pleural PDT as a function of treatment time, treatment volume and surface area. The accuracy of treatment delivery is analyzed as a function of the calibration accuracies of each isotropic detector and the calibration integrating sphere. The patients studied here are enrolled in a Phase I clinical trial of HPPH-mediated PDT for the treatment of non-small cell lung cancer with pleural effusion. Patients are administered 4mg per kg body weight HPPH 24-48 hours before the surgery. Patients undergoing photodynamic therapy (PDT) are treated with light therapy with a fluence of 15-60 J/cm(2) at 661nm. Fluence rate (mW/cm(2)) and cumulative fluence (J/cm(2)) is monitored at 7 different sites during the entire light treatment delivery. Isotropic detectors are used for in-vivo light dosimetry. The anisotropy of each isotropic detector was found to be within 15%. The mean fluence rate delivery and treatment time are recorded. A correlation between the treatment time and the treatment volume is established. The result can be used as a clinical guideline for future pleural PDT treatment.

引用

页数：6

共 7 条

[1] In vivo light dosimetry for motexafin lutetium-mediated PDT of recurrent breast cancer [J].

Dimofte, A ;

Zhu, TC ;

Hahn, SM ;

Lustig, RA .

LASERS IN SURGERY AND MEDICINE, 2002, 31 (05) :305-312

[2]

DIMOFTE A, 2009, P SPIE, V7164

[3]

Finlay J.C., 2009, P SPIE, V7164

[4] Hemoglobin oxygen saturations in phantoms and in vivo from measurements of steady-state diffuse reflectance at a single, short source-detector separation [J].

Finlay, JC ;

Foster, TH .

MEDICAL PHYSICS, 2004, 31 (07) :1949-1959

[5] Phase II trial of pleural photodynamic therapy and surgery for patients with non-small-cell lung cancer with pleural spread [J].

Friedberg, JS ;

Mick, R ;

Stevenson, JP ;

Zhu, T ;

Busch, TM ;

Shin, D ;

Smith, D ;

Culligan, M ;

Dimofte, A ;

Glatstein, E ;

Hahn, SM .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (11) :2192-2201

[6]

JC F, 2006, P SPIE, V6139

[7]

SphereOptics, 2007, INT SPHER DES APPL T, P4

← 1 →